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Effect of Continuous Positive Airway Pressure Therapy on Blood Levels of Il-6, Il-10, Il-18, Il-1Β, Il-4, and Il-17 in Obstructive Sleep Apnoea Adults: A Systematic Review, Meta-Analysis and Trial Sequential Analysis Publisher Pubmed



Mohammadi I1 ; Adibparsa M2 ; Yashooa RK3 ; Sehat MS1 ; Sadeghi M4
Authors
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Authors Affiliations
  1. 1. Oral and Maxillofacial Surgery Department, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Plastic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Department of Medical Microbiology, College of Science, Knowledge University, Kirkuk Road, Erbil, 44001, Kurdistan Region, Iraq
  4. 4. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 67144-15185, Iran

Source: International Orthodontics Published:2024


Abstract

Introduction: Obstructive sleep apnoea (OSA) is a long-term disorder characterized by frequent blockages in the upper respiratory tract during sleep, often leading to abrupt awakenings, with or without a decrease in oxygen levels. The systematic review and meta-analysis aimed to assess the effect of continuous positive airway pressure therapy (CPAP) on blood interleukin (IL) levels of IL-6, IL-10, IL-18, IL-1β, IL-4, and IL-17 in OSA adults. Materials and methods: The published databases from PubMed, Scopus, Web of Science, and Cochrane Library were searched from 2003 to 2024, without any restrictions. The Review Manager software 5.3 was employed to compute effect sizes, which were presented as the standardized mean difference (SMD) along with a 95% confidence interval (CI). Results: In total, 320 records were identified through database searching; ultimately, 42 articles were included in the qualitative synthesis and then the meta-analysis. The CPAP therapy significantly reduces IL-6 levels, as indicated SMD = 0.64 [95% CI: 0.35, 0.93] and P < 0.0001. CPAP therapy significantly reduced IL-18 and IL-1β levels in adults with OSA, but there is no significant difference in IL-10, IL-4, or IL-17 levels. Age, blood sample, body mass index, ethnicity, and treatment duration for IL-6 and apnoea-hypopnea index with IL-10 levels were effective factors in the pooled results. Experimentally, there was an interaction between IL-18 and IL-1β. Conclusions: CPAP therapy has a positive impact on inflammatory markers in OSA adults; remarkably, it reduces IL-6 and IL-1β levels. Nevertheless, more evidence (such as the role of ethnicity) and understanding of interactions are needed. © 2024 CEO
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