Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effect of Continuous Positive Airway Pressure Therapy on Blood Levels of Il-6, Il-10, Il-18, Il-1Β, Il-4, and Il-17 in Obstructive Sleep Apnoea Adults: A Systematic Review, Meta-Analysis and Trial Sequential Analysis Publisher Pubmed



Mohammadi I1 ; Adibparsa M2 ; Yashooa RK3 ; Sehat MS1 ; Sadeghi M4
Authors

Source: International Orthodontics Published:2024


Abstract

Introduction: Obstructive sleep apnoea (OSA) is a long-term disorder characterized by frequent blockages in the upper respiratory tract during sleep, often leading to abrupt awakenings, with or without a decrease in oxygen levels. The systematic review and meta-analysis aimed to assess the effect of continuous positive airway pressure therapy (CPAP) on blood interleukin (IL) levels of IL-6, IL-10, IL-18, IL-1β, IL-4, and IL-17 in OSA adults. Materials and methods: The published databases from PubMed, Scopus, Web of Science, and Cochrane Library were searched from 2003 to 2024, without any restrictions. The Review Manager software 5.3 was employed to compute effect sizes, which were presented as the standardized mean difference (SMD) along with a 95% confidence interval (CI). Results: In total, 320 records were identified through database searching; ultimately, 42 articles were included in the qualitative synthesis and then the meta-analysis. The CPAP therapy significantly reduces IL-6 levels, as indicated SMD = 0.64 [95% CI: 0.35, 0.93] and P < 0.0001. CPAP therapy significantly reduced IL-18 and IL-1β levels in adults with OSA, but there is no significant difference in IL-10, IL-4, or IL-17 levels. Age, blood sample, body mass index, ethnicity, and treatment duration for IL-6 and apnoea-hypopnea index with IL-10 levels were effective factors in the pooled results. Experimentally, there was an interaction between IL-18 and IL-1β. Conclusions: CPAP therapy has a positive impact on inflammatory markers in OSA adults; remarkably, it reduces IL-6 and IL-1β levels. Nevertheless, more evidence (such as the role of ethnicity) and understanding of interactions are needed. © 2024 CEO
Related Docs
View other Related Docs
1. Evaluation of Plasma/Serum Adiponectin (An Anti-Inflammatory Factor) Levels in Adult Patients With Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis, Life (2022)
2. Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Life (2023)
3. A Systematic Review With Meta-Analysis to Assess Alzheimer's Disease Biomarkers in Adults With or Without Obstructive Sleep Apnoea, International Orthodontics (2023)
Experts (# of related papers)
View all Related Experts
Babak Amra (10)
Forogh Soltaninejad (7)
Other Related Docs
4. Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea, Advanced Biomedical Research (2019)
5. Frequency of Positional Obstructive Sleep Apnea (Posa) in Patients With Obstructive Sleep Apnea and Differences in Demographic and Clinical Characteristics, Journal of Isfahan Medical School (2018)
6. Continuous Positive Airway Pressure Treatment for Sleep Apnea in Elderly Patients Systematic Review and Meta-Analysis, Sleep and Breathing (2025)
7. Screening Questionnaires for Obstructive Sleep Apnea: An Updated Systematic Review, Oman Medical Journal (2018)
8. Hypoxic Burden to Guide Cpap Treatment Allocation in Patients With Obstructive Sleep Apnoea: A Post Hoc Study of the Isaacc Trial, European Respiratory Journal (2023)
9. Comparison of Therapeutic Approaches to Addicted Patients With Central Sleep Apnea, Tanaffos (2018)
10. Clinical and Polysomnographic Characteristics of Patients With Extreme Obstructive Sleep Apnea, Ahi > 100: A Case-Control Study, Shiraz E Medical Journal (2021)
11. Evaluating Pharmacological Treatments for Excessive Daytime Sleepiness in Obstructive Sleep Apnea: A Comprehensive Network Meta-Analysis and Systematic Review, Sleep Medicine Reviews (2024)
12. Non Invasive Ventilation's Effectiveness (Niv) in Patients With Interstitial Lung Disease and Hypercapnic Respiratory Failure, Tanaffos (2022)
13. Comparison of Berlin Questionnaire, Stop-Bang, and Epworth Sleepiness Scale for Diagnosing Obstructive Sleep Apnea in Persian Patients, International Journal of Preventive Medicine (2018)
14. Association of Irritable Bowel Syndrome and Sleep Apnea in Patients Referred to Sleep Laboratory, Journal of Research in Medical Sciences (2017)
15. The Relationship Between Sleep Quality and Work Ability Among the Employees of Isfahan University of Medical Sciences, Iran, in Year 2017, Journal of Isfahan Medical School (2019)
16. Polysomnography Findings of Patients With Overlap Syndrome According to Severity of Lower Airway Obstruction, Journal of Research in Medical Sciences (2021)
17. Hypoxic Burden Based on Automatically Identified Desaturations Is Associated With Adverse Health Outcomes, Annals of the American Thoracic Society (2023)
18. Determination of the Incidence of Cardiovascular Composite Events in Patients With Obstructive Sleep Apnea: A 3-Year Follow-Up Study, ARYA Atherosclerosis (2023)
19. Association Between Sleep Duration and Hypertension Incidence: Systematic Review and Meta-Analysis of Cohort Studies, PLoS ONE (2024)
20. Effect of One-Shot Cognitive Behavioral Therapy on Insomnia and Heart Rate Variability of Health Care Workers at the Time of Covid-19 Pandemic: A Randomized Controlled Trial, Sleep and Breathing (2023)