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Lipopolysaccharide-Induced Memory Impairment in Rats Is Preventable Using 7-Nitroindazole; [O Deficit De Memoria Induzido Por Lipossacarideos Em Ratos E Prevenido Por Nitroindazol] Publisher Pubmed



Anaeigoudari A1 ; Shafei MN1 ; Soukhtanloo M2 ; Sadeghnia HR3 ; Reisi P4 ; Beheshti F1 ; Mohebbati R5 ; Mousavi SM5 ; Hosseini M5
Authors
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Authors Affiliations
  1. 1. Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Arquivos de Neuro-Psiquiatria Published:2015


Abstract

Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI. © 2015, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.
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