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Neuronal Nitric Oxide Synthase Has a Role in the Detrimental Effects of Lipopolysaccharide on Spatial Memory and Synaptic Plasticity in Rats Publisher Pubmed



Anaeigoudari A1 ; Soukhtanloo M2 ; Shafei MN3 ; Sadeghnia HR4 ; Reisi P5 ; Beheshti F1 ; Behradnia S3 ; Mousavi SM3 ; Hosseini M1
Authors
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Authors Affiliations
  1. 1. Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Pharmacological Reports Published:2016


Abstract

Background The role of neuronal nitric oxide synthase (nNOS) in lipopolysaccharide (LPS)-induced memory and synaptic plasticity impairment was investigated. Methods The rats were divided and treated as follows: (1) control (saline), (2) LPS, (3) 7NI (7-nitroindazole as a nNOS inhibitor)-LPS and (4) 7NI. Results In a Morris water maze, the LPS group took a longer amount of time and traveled a greater distance to reach the platform, this was prevented by 7NI. Malondialdehyde (MDA) and nitric oxide (NO) metabolites in the hippocampus of the LPS group were higher while the total thiol, superoxide dismutase and catalase were lower than that of the controlled specimen. Pre-treatment using 7NI prevented the changes in the biochemical criteria. The slope and amplitude of the field excitatory post-synaptic potential (fEPSP) in the LPS group decreased, whereas in 7NI-LPS group they increased. Conclusion It is suggested that inhibition of nNOS by 7NI improves the deleterious effects of LPS by reducing NO metabolites and the brain tissues oxidative damage. © 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.
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