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The Therapeutic Effect of Combination of X-Ray and Iron Oxide Nanoparticles Attached to Dacarbazine Chemotherapy Drug on Melanoma Cell Line Publisher



Abadi ARS1 ; Shanei A1 ; Attaran N2 ; Hejazi SH3 ; Najafizadeh N4
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Radiooncology, School of Medicine, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2022


Abstract

Background: Due to the inherent resistance of melanoma cells to radiation, high doses of radiation are required to treat skin cancer, which increases the side effects from radiation. The use of iron oxide nanoparticles can make melanoma cells more sensitive to radiation and increase cell death. The aim of this study was to investigate the effects of iron oxide nanoparticles conjugated with dacarbazine in the presence of megavoltage X-ray. Methods: After culturing A375 cells in vitro and grouping the cells, the optimal concentrations of iron oxide nanoparticles and dacarbazine were calculated separately by MTT assay. Concentrations of 0.4, 0.7 and 1.5 mg / ml of dacarbazine were then combined with non-toxic concentrations of iron oxide nanoparticles. The amount of induced apoptosis in irradiated cells with 6 MV energy and 4 Gy radiation dose was calculated and compared with apoptosis in non-irradiated cells. Findings: The rate of apoptosis in melanoma cells treated with a combination of iron oxide nanoparticles with dacarbazine increased by 50%. This rate increased to the maximum with cell irradiation, which is 30% higher than the mortality rate in the control group. Conclusion: Concomitant use of iron oxide nanoparticles with dacarbazine can increase the response of melanoma cells to treatment. The use of this compound in the presence of radiation also causes a significant reduction in cell survival, which indicates the sensitizing effect of iron oxide nanoparticles. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.
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