Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Investigating the Effectiveness of 6 Mev Electron and Ultrasound Beams With the Use of Iron Oxide Magnetic Nanoparticles Attached to Cisplatin on B16f10 Cells: In-Vitro Study Publisher



Garshad J1 ; Shanei A1 ; Hossein Hejazi S2 ; Abedi I1 ; Attaran Kakhki N3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department Of Medical Physics, School Of Medicine, Isfahan University Of Medical Sciences, Isfahan, Iran
  2. 2. Department Of Parasitology And Mycology, School Of Medicine, Skin Diseases And Leishmaniasis Research Center, Isfahan University Of Medical Sciences, Isfahan, Iran
  3. 3. Department Of Medical Nanotechnology, Islamic Azad University, Tehran, Iran

Source: International Journal of Nanoscience Published:2024


Abstract

Melanoma is considered the deadliest skin cancer that can be treated with surgery, radiotherapy, chemotherapy, etc. The use of magnetic iron oxide nanoparticles (IONPs) in order to increase the effectiveness of electron beams and ultrasound beams by increasing the production of free radicals (ROS) and their ability to deliver chemotherapy drugs is under research. Cisplatin is one of the chemotherapy drugs based on platinum, whose ability to deal with melanoma has recently been clarified. In this study, we studied the synthesis of Fe2O3, Fe2O3@L-Aspartic and Fe2O3@L-Aspartic@Cisplatin nanoparticles and we managed to determine the characteristics of each of them using TEM, DLS, FTIR, UV-Vis tests; also, MTT and flow cytometry tests were performed for Fe2O3 and Fe2O3@L-Aspartic with the concentrations of 10, 25, 50, 80 and 100 μ g/mL and for Fe2O3@L-Aspartic@Cisplatin and cisplatin with concentrations of 0.6, 1.6, 5, 10 and 20 μ g/mL alone and in combination with electron beam with doses of 1 Gy, 2Gy and 3Gy and ultrasound beam with the intensities of 1W/cm2 and 2W/cm2. The results of the mining TEM test show the size of Fe2O3, Fe2O3@L-Aspartic and Fe2O3@L-Aspartic@Cisplatin to be 25nm, 35nm and 42nm, and the FTIR and UV-Vis tests also confirmed the nanoparticle coating and drug loading; also, the results of MTT and flow cytometry test showed the effectiveness of Fe2O3, Fe2O3@L-Aspartic and Fe2O3@L-Aspartic@Cisplatin in increasing the effectiveness of electron beam and ultrasound beam. The use of nanotechnology together with other treatment methods can shed light on a new way to overcome cancer. © 2024 World Scientific Publishing Company.
Related Docs
View other Related Docs
1. Efficacy Study of 6 Mev Electron Beam in the Presence of Magnetic Iron Oxide Nanoparticles Conjugated to Cisplatin on B16f10 Cells: An In-Vitro Study, Applied Physics A: Materials Science and Processing (2024)
2. Assessment of Ploy Dopamine Coated Fe3o4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection, Anti-Cancer Agents in Medicinal Chemistry (2020)
3. The Therapeutic Effect of Combination of X-Ray and Iron Oxide Nanoparticles Attached to Dacarbazine Chemotherapy Drug on Melanoma Cell Line, Journal of Isfahan Medical School (2022)
4. In-Vitro Toxicity Assessment of Polydopamine-Coated and Uncoated Fe3o4 Nanoparticles in Cell Line B16-F10 (Melanoma Cell), Journal of Isfahan Medical School (2019)
5. Synthesis and Cytotoxicity Assessment of Gold-Coated Magnetic Iron Oxide Nanoparticles, Journal of Biomedical Physics and Engineering (2018)
6. Targeted Photothermal Therapy of Melanoma in C57bl/6 Mice Using Fe3 O4 @Au Core-Shell Nanoparticles and Near-Infrared Laser, Journal of Biomedical Physics and Engineering (2021)
7. Biosynthesis of Core–Shell Α-Fe2o3@Au Nanotruffles and Their Biomedical Applications, Biomass Conversion and Biorefinery (2024)
8. Doxorubicin Hydrochloride - Loaded Electrospun Chitosan/Cobalt Ferrite/Titanium Oxide Nanofibers for Hyperthermic Tumor Cell Treatment and Controlled Drug Release, International Journal of Biological Macromolecules (2018)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (23)
Seyed Hossein Hejazi (5)
Other Related Docs
9. Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6, Journal of Isfahan Medical School (2021)
10. Synthesis, Characterization and Mri Application of Cobalt-Zinc Ferrite Nanoparticles Coated With Dmsa: An In-Vivo Study, Applied Magnetic Resonance (2021)
11. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
12. Iron Oxyhydroxide Nanoparticles: Green Synthesis and Their Cytotoxicity Activity Against A549 Human Lung Adenocarcinoma Cells, Rendiconti Lincei (2022)
13. The Role of Folic Acid-Conjugated Polyglycerol Coated Iron Oxide Nanoparticles on Radiosensitivity With Clinical Electron Beam (6 Mev) on Human Cervical Carcinoma Cell Line: In Vitro Study, Journal of Photochemistry and Photobiology B: Biology (2018)
14. Targeting Ferroptosis As a Cell Death Pathway in Melanoma: From Molecular Mechanisms to Skin Cancer Treatment, International Immunopharmacology (2023)
15. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
16. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
17. Optimal Scheduling of the Nanoparticle-Mediated Cancer Photo-Thermo-Radiotherapy, Photodiagnosis and Photodynamic Therapy (2020)
18. Could Fa-Pg-Spions Act As a Hyperthermia Sensitizing Agent? an in Vitro Study, Journal of Thermal Biology (2018)
19. Hydroxypyridinone Derivatives: Synthesis and Cytotoxic Evaluation, Journal of Reports in Pharmaceutical Sciences (2013)
20. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
21. Catalytic Effect of Fe@Fe2o3 Nanowires and Fenton Process on Carbamazepine Removal From Aqueous Solutions Using Response Surface Methodology, Global Journal of Environmental Science and Management (2019)
22. Superparamagnetic Iron Oxide Nanoparticle-Loaded Nanodroplets for Dual-Modal Ultrasound/Magnetic Resonance Imaging-Guided Drug Delivery, New Journal of Chemistry (2023)
23. Preparation and Cytotoxic Evaluation of Magnetite (Fe3o4) Nanoparticleon Breast Cancer Cells and Its Combinatory Effects With Doxorubicin Used in Hyperthermia, Avicenna Journal of Medical Biotechnology (2013)
24. The Effect of Ultrasound Therapy in the Presence of Combined Zinc Oxide/Gold Nanocomposite on Melanoma Cell Line, Journal of Isfahan Medical School (2023)
25. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
26. Mtx-Loaded Dual Thermoresponsive and Ph-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer, Molecular Pharmaceutics (2021)
27. Trastuzumab Conjugated Porphyrin-Superparamagnetic Iron Oxide Nanoparticle: A Potential Ptt-Mri Bimodal Agent for Herceptin Positive Breast Cancer, Photodiagnosis and Photodynamic Therapy (2020)
28. Functionalized Magnetic Nanoparticles for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices (2024)
29. Lomustine Loaded Superparamagnetic Iron Oxide Nanoparticles Conjugated With Folic Acid for Treatment of Glioblastoma Multiforma (Gbm), Iranian Journal of Pharmaceutical Research (2020)
30. Cobalt Zinc Ferrite Nanoparticles As a Potential Magnetic Resonance Imaging Agent: An in Vitro Study, Avicenna Journal of Medical Biotechnology (2015)
31. Nitrate Removal From Aqueous Solutions by Magnetic Nanoparticle, Journal of Environmental Health and Sustainable Development (2017)
32. Magnetic Iron Oxide Nanoparticles As T2 Mr Imaging Contrast Agent for Detection of Breast Cancer (Mcf-7) Cell, Avicenna Journal of Medical Biotechnology (2017)
33. Solvothermal Synthesis of Magnetic Spinel Ferrites, Journal of Medical Signals and Sensors (2018)
34. Biodistribution and Toxicity Assessment of Radiolabeled and Dmsa Coated Ferrite Nanoparticles in Mice, Journal of Radioanalytical and Nuclear Chemistry (2012)
35. In Vivo Study of Anti-Epidermal Growth Factor Receptor Antibody-Based Iron Oxide Nanoparticles (Anti-Egfr-Spions) As a Novel Mr Imaging Contrast Agent for Lung Cancer (Llc1) Cells Detection, IET Nanobiotechnology (2020)
36. Synthesis and Application of Fe3o4@Au Composite Nanoparticles As Magnetic Resonance/Computed Tomography Dual-Modality Contrast Agent, Journal of Medical Signals and Sensors (2020)
37. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
38. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
39. Synergistic Effect of the Combination of Triethylene-Glycol Modified Fe3o4 Nanoparticles and Ultrasound Wave on Mcf-7 Cells, Journal of Magnetism and Magnetic Materials (2015)
40. Synthesis and Characterization of Core-Shell Fe 3O 4-Gold-Chitosan Nanostructure, Journal of Nanobiotechnology (2012)
41. An Investigation on Polycaprolactone/Chitosan/Fe3o4 Nanofibrous Composite Used for Hyperthermia, Polymers for Advanced Technologies (2019)
42. Papain Grafted Into the Silica Coated Iron-Based Magnetic Nanoparticles 'Ionps@Sio2-Ppn' As a New Delivery Vehicle to the Hela Cells, Nanotechnology (2020)
43. Gold-Coated Iron Oxide Nanoparticles As a Potential Photothermal Therapy Agent to Enhance Eradication of Breast Cancer Cells, Journal of Physics: Conference Series (2020)
44. Multifunctional Magnetic Nanostructured Hardystonite Scaffold for Hyperthermia, Drug Delivery and Tissue Engineering Applications, Materials Science and Engineering C (2017)
45. Preparation and Magnetic Properties Investigation of Fe3o4 Nanoparticles Labaled With 99Mtc Radioisotope and Fe3o4 Nanoparticles Dmsa Coated, Digest Journal of Nanomaterials and Biostructures (2011)
46. Thermosensitive Tmpo-Oxidized Lignocellulose/Cationic Agarose Hydrogel Loaded With Deferasirox Nanoparticles for Photothermal Therapy in Melanoma, International Journal of Biological Macromolecules (2023)
47. Study the Anti-Muc1 Antibody-Based Iron Oxide Nanoparticles on Three-Dimension Spheroid and Breast Cancer (Mcf-7) Cell Imaging, Polish Journal of Medical Physics and Engineering (2019)
48. In Vitro Study of Spions-C595 As Molecular Imaging Probe for Specific Breast Cancer (Mcf-7) Cells Detection, Iranian Biomedical Journal (2017)
49. Architecting Ultra-Thin Sio2 Shell for High Magnetic Performance of Fe3o4 Nanoparticles for Biomedical Applications, Inorganic Chemistry Communications (2024)
50. Iron Oxide Nanoparticles Coated With Polydopamine As a Potential Nano-Photothermal Agent for Treatment of Melanoma Cancer: An in Vivo Study, Lasers in Medical Science (2022)