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Doxorubicin Hydrochloride - Loaded Electrospun Chitosan/Cobalt Ferrite/Titanium Oxide Nanofibers for Hyperthermic Tumor Cell Treatment and Controlled Drug Release Publisher Pubmed



Radmansouri M1 ; Bahmani E2 ; Sarikhani E3 ; Rahmani K3 ; Sharifianjazi F4 ; Irani M5
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
  4. 4. Department of Metallurgy & Material Engineering, Golpayegan University of Technology, Golpayegan, Iran
  5. 5. Young Researchers & Elite Club, Tehran North Branch, Islamic Azad University, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2018


Abstract

In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometer (VSM) analysis. The DOX loading efficiency and in vitro drug release of DOX from nanofibers were investigated at both physiological and acidic conditions by an alternating of magnetic field and without magnetic field effect. The fastest release of DOX from prepared magnetic nanofibers was observed at acidic pH by alternating of magnetic field. The antitumor activity of synthesized nanofibers was also investigated on the melanoma cancer B16F10 cell lines. The obtained results revealed that the DOX loaded-electrospun chitosan/cobalt ferrite/titanium oxide nanofibers can be used for localized cancer therapy. © 2018 Elsevier B.V.
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