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Generation of Pgs/Pcl Blend Nanofibrous Scaffolds Mimicking Corneal Stroma Structure Publisher



Salehi S1, 4 ; Fathi M1 ; Javanmard SH5 ; Bahners T2, 9 ; Gutmann JS2, 6 ; Ergun S7 ; Steuhl KP8 ; Fuchsluger TA3
Authors
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Authors Affiliations
  1. 1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran
  2. 2. Deutsches Textilforschungzentrum Nord-West GGmbH, 47798 Krefeld, Adlerstr. 1, Germany
  3. 3. Institute of Anatomy, Essen University Hospital, University of Duisburg-Essen, Essen 45122, Germany
  4. 4. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran
  5. 5. Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran
  6. 6. Physikalische Chemie, Universitat Duisburg-Essen, 45141 Essen, Universitatsstr. 5, Germany
  7. 7. Institute of Anatomy and Cell Biology, Julius-Maximilians-University Wurzburg, Wurzburg D-97070, Germany
  8. 8. Center of Ophthalmology, Essen University Hospital, University of Duisburg-Essen, Essen 45122, Germany
  9. 9. Department of Ophthalmology, Dusseldorf University Hospital, Heinrich-Heine-University, Dusseldorf 40225, Germany

Source: Macromolecular Materials and Engineering Published:2014


Abstract

Morphological studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(-caprolactone)(PCL) blends for application as corneal tissue scaffolds are presented. Parallel conductive bars are used as ground electrode to generate unidirectional nanofibers. Scaffolds have fibers diameter in the range of 550-300nm. The structural stability and wettability, especially the in vitro degradation rate, of the electrospun scaffolds can be controlled by regulating the blended ratio of the polymers. The results indicate that PGS/PCL nanofiber scaffolds can be considered as ideal candidates for corneal tissue engineering scaffolds. The particular motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of the cornea. Morphological and degradation studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(-caprolactone)(PCL) blends for corneal tissue engineering are reported. Scaffolds have fibers diameter in the range of 550-300nm. The motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of cornea. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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