Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Novel Electrospun Polyurethane Scaffolds Containing Bioactive Glass Nanoparticles Publisher



Yazdani I1 ; Naeimi M1 ; Sattary M2 ; Rafienia M3 ; Movahedi B1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nanotechnology Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
  2. 2. Biomedical Engineering Department, Islamic Azad University Central, Tehran Branch, Tehran, Iran
  3. 3. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine (ATiM), Isfahan University of Medical Sciences, Isfahan, Iran

Source: Bioinspired, Biomimetic and Nanobiomaterials Published:2020


Abstract

In the present study, polyurethane (PU) nanocomposite scaffolds containing bioactive glass nanoparticles (BG-NPs) were successfully fabricated through the electrospinning process. The BG-NPs were synthesized through the sol-gel method. PU solutions (10%w/v) containing different weight percentages of the BG-NPs (5, 10 and 15wt.%) in dimethylformamide/tetrahydrofuran were prepared. To determine both the size of BG-NPs and the diameter of the nanofibers, transmission electron microscopy and scanning electron microscopy were carried out. The surface morphology, mechanical properties, bioactivity and degradation rate of the scaffolds were studied. Fourier transform infrared spectroscopy, X-ray diffraction and energy-dispersive X-ray spectroscopy confirmed the presence of BG within the scaffolds. The tensile strength of nanocomposite scaffolds was in the range 5-8MPa, which is in good agreement with the tensile strength of cancellous bone tissue. MG63 cells attached to and proliferated well within the scaffolds; therefore, cellular growth was also improved in the nanocomposite scaffolds. Based on the results, the novel PU/BG-NP (10wt.%) nanocomposite scaffold has a great potential to be applied in cancellous bone tissue engineering. © 2020 ICE Publishing: All rights reserved.
Related Docs
View other Related Docs
1. Effects of Nano-Bioactive Glass on Structural, Mechanical and Bioactivity Properties of Poly (3-Hydroxybutyrate) Electrospun Scaffold for Bone Tissue Engineering Applications, Materials Technology (2019)
2. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
3. A New Approach to Fabrication of Cs/Bg/Cnt Nanocomposite Scaffold Towards Bone Tissue Engineering and Evaluation of Its Properties, Applied Surface Science (2015)
4. Potential of Novel Electrospun Core-Shell Structured Polyurethane/Starch (Hyaluronic Acid) Nanofibers for Skin Tissue Engineering: In Vitro and in Vivo Evaluation, International Journal of Biological Macromolecules (2020)
5. Poly (Ε-Caprolactone) Incorporated Bioactive Glass Nanoparticles and Simvastatin Nanocomposite Nanofibers: Preparation, Characterization and in Vitro Drug Release for Bone Regeneration Applications, Chemical Engineering Journal (2013)
6. Tunable Cellular Interactions and Physical Properties of Nanofibrous Pcl-Forsterite: Gelatin Scaffold Through Sequential Electrospinning, Composites Science and Technology (2013)
7. Electrospun Polycaprolactone/Lignin-Based Nanocomposite As a Novel Tissue Scaffold for Biomedical Applications, Journal of Medical Signals and Sensors (2017)
8. Electrospun Phbv Nanofibers Containing Ha and Bredigite Nanoparticles: Fabrication, Characterization and Evaluation of Mechanical Properties and Bioactivity, Composites Science and Technology (2015)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (93)
Mohammad Rafienia (60)
Other Related Docs
9. Mechanical Property of Poly (3-Hydroxybutyrate)/Bioglass Nanocomposite Scaffolds for Bone Tissue Engineering, IFMBE Proceedings (2010)
10. Ultra-Thin Electrospun Nanocomposite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Magnetic Mesoporous Bioactive Glasses for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2024)
11. The Electrospun Poly(Ε-Caprolactone)/Fluoridated Hydroxyapatite Nanocomposite for Bone Tissue Engineering, Polymers for Advanced Technologies (2020)
12. Fabrication and Characterization of Novel Polyhydroxybutyrate-Keratin/Nanohydroxyapatite Electrospun Fibers for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
13. Evaluation of Mechanical Property and Bioactivity of Nano-Bioglass 45S5 Scaffold Coated With Poly-3-Hydroxybutyrate, Journal of Materials Science: Materials in Medicine (2015)
14. Comparison of Acellular and Cellular Bioactivity of Poly 3-Hydroxybutyrate/Hydroxyapatite Nanocomposite and Poly 3-Hydroxybutyrate Scaffolds, Biotechnology and Bioprocess Engineering (2013)
15. Preparing Nanocomposite Fibrous Scaffolds of P3hb/Nha for Bone Tissue Engineering, 2010 17th Iranian Conference of Biomedical Engineering, ICBME 2010 - Proceedings (2010)
16. Evaluation of Mg63 Cells Behavior With Electrospun Nanocomposite Scaffolds of Polycaprolactone and Carbon Quantum Dot Containing Captopril for Bone Tissue Engineering, Journal of Knowledge and Health in Basic Medical Sciences (2020)
17. Morphology and Degradation of Poly (3-Hydroxybutyrate)/ Nano-Hydroxyapatite Scaffold Used in Tissue Engineering, Journal of Isfahan Medical School (2012)
18. Effects of Surface Modification on the Mechanical and Structural Properties of Nanofibrous Poly(Ε-Caprolactone)/Forsterite Scaffold for Tissue Engineering Applications, Materials Science and Engineering C (2013)
19. Effects of Bioglass Nanoparticles on Bioactivity and Mechanical Property of Poly(3-Hydroxybutirate) Scaffolds, Scientia Iranica (2013)
20. Effect of Cellulose Nanofibers on Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
21. Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies, Polymers for Advanced Technologies (2020)
22. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)
23. A Ternary Nanocomposite Fibrous Scaffold Composed of Poly(Ε-Caprolactone)/Gelatin/Gehlenite (Ca2al2sio7): Physical, Chemical, and Biological Properties in Vitro, Polymers for Advanced Technologies (2021)
24. Incorporation of Mesoporous Silica Nanoparticles Into Random Electrospun Plga and Plga/Gelatin Nanofibrous Scaffolds Enhances Mechanical and Cell Proliferation Properties, Materials Science and Engineering C (2016)
25. Polyhydroxybutyrate/Chitosan/Bioglass Nanocomposite As a Novel Electrospun Scaffold: Fabrication and Characterization, Journal of Porous Materials (2017)
26. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
27. Preparation of a Novel Biodegradable Nanocomposite Scaffold Based on Poly (3-Hydroxybutyrate)/Bioglass Nanoparticles for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2010)
28. Preparation of Fibrin/Poly Vinyl Alcohol Electrospun Nanofibers Scaffold for Tissue Engineering Applications, Journal of Isfahan Medical School (2016)
29. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
30. Nanobiomaterials in Periodontal Tissue Engineering, Nanobiomaterials in Hard Tissue Engineering: Applications of Nanobiomaterials (2016)
31. The Effect of Collector Type on the Physical, Chemical, and Biological Properties of Polycaprolactone/Gelatin/Nano-Hydroxyapatite Electrospun Scaffold, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2019)
32. Electrospun Core-Shell Polycaprolactone/ Chitosan Nanofibrous Composite With Enhanced Curcumin Loading Capacity for Wound Healing Applications, Materials Today Chemistry (2024)
33. A Core-Shell Electrospun Scaffold of Polyhydroxybutyrate-Starch/Halloysite Nanotubes Containing Extracellular Matrix and Chitosan for Articular Cartilage Tissue Engineering Application, Journal of Polymers and the Environment (2023)
34. Evaluation of Physical and Mechanical Properties of Fi-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nanocomposite Scaffold for Bone Tissue Engineering Application, Scientia Iranica (2017)
35. Biodegradable Nanocomposite Coatings Accelerate Bone Healing: In Vivo Evaluation, Dental Research Journal (2015)
36. Nano/Micro Hybrid Scaffold of Pcl or P3hb Nanofibers Combined With Silk Fibroin for Tendon and Ligament Tissue Engineering, Journal of Applied Biomaterials and Functional Materials (2015)
37. Plasma Surface Modification of Electrospun Polyhydroxybutyrate (Phb) Nanofibers to Investigate Their Performance in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
38. Baghdadite/Polycaprolactone Nanocomposite Scaffolds: Preparation, Characterisation, and in Vitro Biological Responses of Human Osteoblast-Like Cells (Saos-2 Cell Line), Materials Technology (2020)
39. Preparation of Nanostructure Bioactive Diopside Scaffolds for Bone Tissue Engineering by Two Near Net Shape Manufacturing Techniques, Materials Letters (2016)
40. Poly (Glycerol Sebacate) and Polyhydroxybutyrate Electrospun Nanocomposite Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells, Journal of Drug Delivery Science and Technology (2021)
41. Evaluation of the Effects of Multiwalled Carbon Nanotubes on Electrospun Poly(3-Hydroxybutirate) Scaffold for Tissue Engineering Applications, Journal of Porous Materials (2018)
42. Controlled Release of Metronidazole Benzoate From Poly Ε-Caprolactone Electrospun Nanofibers for Periodontal Diseases, European Journal of Pharmaceutics and Biopharmaceutics (2010)
43. Poly Glycerol Sebacate/ Polycaprolactone/ Carbon Quantum Dots Fibrous Scaffold As a Multifunctional Platform for Cardiac Tissue Engineering, Materials Chemistry and Physics (2021)
44. Potential of an Electrospun Composite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Alumina Nanowires in Bone Tissue Engineering Applications, Materials Science and Engineering C (2019)
45. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
46. Characterization of Silk/Poly 3-Hydroxybutyrate-Chitosan-Multi-Walled Carbon Nanotube Micro-Nano Scaffold: A New Hybrid Scaffold for Tissue Engineering Applications, Journal of Medical Signals and Sensors (2018)
47. Synthesis of Polyurethane/Hyaluronic Acid/Royal Jelly Electrospun Scaffold and Evaluating Its Properties for Wound Healing, Journal of Mazandaran University of Medical Sciences (2021)
48. Incorporation of Multi-Walled Carbon Nanotubes Into Electrospun Pcl/Gelatin Scaffold: The Influence on the Physical, Chemical and Thermal Properties and Cell Response for Tissue Engineering, Materials Technology (2020)
49. Physical, Mechanical, and Biological Performance of Chitosan-Based Nanocomposite Coating Deposited on the Polycaprolactone-Based 3D Printed Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
50. Optimization and Characterization of Polyhydroxybutyrate/Lignin Electro-Spun Scaffolds for Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)