Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst

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Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst Publisher

Summary: Research shows chitosan-based material helps synthesize cancer drugs efficiently, promising new treatments. #CancerResearch #Nanotechnology

Khorsandi Z^{1, 2} ; Keshavarzipour F² ; Varma RS³ ; Hajipour AR¹ ; Sadeghialiabadi H²

Source: Molecular Catalysis Published:2022

Abstract

Herein, chitosan as an inexpensive, abundant, and biodegradable bio-material, produced from a key constituent of the exoskeletons of crustaceans, was used to generate the cobalt-based magnetic silica nanocomposite for the performance of the C-N cross-coupling reaction as the main step of the synthesis of Abemaciclib and Fedratinibs. Several derivatives of these recently FDA-approved anti-cancer drugs were synthesized for the first time by using Pd/Cu-free co-catalyzed under both, the conventional heating and microwave (MW) irradiation conditions. The potential anticancer activity of synthesized compounds was investigated by molecular docking study. © 2021

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Style	Citing Format
MLA	Khorsandi Z, et al.. "Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst." Molecular Catalysis, vol. 517, no. , 2022, pp. -.
APA	Khorsandi Z, Keshavarzipour F, Varma RS, Hajipour AR, Sadeghialiabadi H (2022). Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst. Molecular Catalysis, 517(), -.
Chicago	Khorsandi Z, Keshavarzipour F, Varma RS, Hajipour AR, Sadeghialiabadi H. "Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst." Molecular Catalysis 517, no. (2022): -.
Harvard	Khorsandi Z et al. (2022) 'Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst', Molecular Catalysis, 517(), pp. -.
Vancouver	Khorsandi Z, Keshavarzipour F, Varma RS, Hajipour AR, Sadeghialiabadi H. Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst. Molecular Catalysis. 2022;517():-.
BibTex	@article{ author = {Khorsandi Z and Keshavarzipour F and Varma RS and Hajipour AR and Sadeghialiabadi H}, title = {Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst}, journal = {Molecular Catalysis}, volume = {517}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Khorsandi Z AU - Keshavarzipour F AU - Varma RS AU - Hajipour AR AU - Sadeghialiabadi H TI - Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst JO - Molecular Catalysis VL - 517 IS - SP - EP - PY - 2022 ER -

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