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Sustainable Synthesis of Potential Antitumor New Derivatives of Abemaciclib and Fedratinib Via C-N Cross Coupling Reactions Using Pd/Cu-Free Co-Catalyst Publisher



Khorsandi Z1, 2 ; Keshavarzipour F2 ; Varma RS3 ; Hajipour AR1 ; Sadeghialiabadi H2
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156, Iran
  2. 2. Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, ˇSlechtitelu 27, Olomouc, 783 71, Czech Republic

Source: Molecular Catalysis Published:2022


Abstract

Herein, chitosan as an inexpensive, abundant, and biodegradable bio-material, produced from a key constituent of the exoskeletons of crustaceans, was used to generate the cobalt-based magnetic silica nanocomposite for the performance of the C-N cross-coupling reaction as the main step of the synthesis of Abemaciclib and Fedratinibs. Several derivatives of these recently FDA-approved anti-cancer drugs were synthesized for the first time by using Pd/Cu-free co-catalyzed under both, the conventional heating and microwave (MW) irradiation conditions. The potential anticancer activity of synthesized compounds was investigated by molecular docking study. © 2021
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