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Synthesis and Characterization of Core-Shell Fe 3O 4-Gold-Chitosan Nanostructure Publisher Pubmed



Salehizadeh H1, 2 ; Hekmatian E3 ; Sadeghi M2 ; Kennedy K1
Authors
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Authors Affiliations
  1. 1. Department of Civil Engineering, University of Ottawa, Ottawa, ON, K1N 6N5, Canada
  2. 2. Biotechnology Engineering Group, University of Isfahan, Isfahan, Iran
  3. 3. Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran

Source: Journal of Nanobiotechnology Published:2012


Abstract

Background: Fe 3O 4-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment.Results: Magnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe 3O 4 monotonous core-shell nanostructure was produced with an average size of 15 nm in diameter by glucose reduction of Au 3+ which is then stabilized with a chitosan cross linked by formaldehyde. The results of analyses with X-ray diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution.Conclusions: A rapid, mild method for synthesizing Fe 3O 4-gold nanoparticles using chitosan was investigated. A magnetic core-shell-chitosan nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized. © 2012 Salehizadeh et al; licensee BioMed Central Ltd.
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