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Fluorescence Resonance Energy Transfer Monitoring of Ph-Responsive Doxorubicin Release From Carbon Dots/Aptamer Functionalized Magnetic Mesoporous Silica Publisher Pubmed



Kajani AA1, 2 ; Mehrgardi MA2
Authors
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Authors Affiliations
  1. 1. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 81746 73461, Iran
  2. 2. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran

Source: Nanomedicine Published:2021


Abstract

Aim: To develop a novel theranostic nanoplatform for simultaneous fluorescent monitoring and stimuli-triggered drug delivery. Materials & methods: Different microscopic and spectroscopic techniques were used for the characterization of nanocarriers. MCF-7 and human umbilical vein endothelial cell lines were cultured and treated with different doses of doxorubicin-loaded nanocarriers. The cell viability and drug release were studied using MTT assay and fluorescence microscopy. Results: Biocompatible and mono-disperse nanocarriers represent hollow and mesoporous structures with the calculated surface area of 552.83 m2.g-1, high magnetic activity (12.6 emu.g-1), appropriate colloidal stability and high drug loading capacity (up to 61%). Conclusion: Taxane-based carbon dots act as the pH-responsive gatekeepers for the controlled release of doxorubicin into cancer cells and provide a fluorescence resonance energy transfer system for real-time monitoring of drug delivery. © 2021 Future Medicine Ltd.
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