Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Interactions of Dietary Insulin Index and Dietary Insulin Load With Brain-Derived Neurotrophic Factor (Bdnf) Val66met Polymorphism in Relation to Cardiometabolic Markers in Iranian Diabetic Patients: A Cross-Sectional Study Publisher Pubmed



Abaj F1 ; Rafiee M2 ; Koohdani F3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran
  3. 3. Department of Cellular Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: British Journal of Nutrition Published:2022


Abstract

The progression of cardiometabolic diseases is determined by both genetic and environmental factors. Gene-diet interactions may therefore be important in modulating the risks of developing metabolic diseases. The objectives were to investigate the effect of the interaction between brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms and dietary insulin index (DII) and dietary insulin load (DIL) on cardiometabolic markers among diabetic patients. In this cross-sectional study, blood samples were collected from 667 patients. DIL and DII were defined using a validated FFQ. Genotyping the BDNF Val66Met polymorphism was conducted by the PCR-Restriction fragment length polymorphismA (RFLP) method. Interactions between dietary indices and gene variants were evaluated using a generalised linear model. PGF2a concentrations were significantly higher among Val homozygotes than Met-allele carrier. This study revealed that, compared with individuals with the Val/Val genotype, those with the Met/Val or Met/Met genotype had lower BMI (P interaction = 0·04), TAG (P interaction = 0·04), leptin (P interaction = 0·01), LDL (P interaction = 0·04) and total cholesterol (P interaction = 0·01) when they consumed diets higher on the DIL index. Moreover, the highest quartile of the DIL, compared with the lowest, showed increase in waist circumference (P interaction = 0·02) and LDL/HDL (P interaction = 0·04) for Val/Val homozygotes compared with Met-allele carriers. BDNF Val66Met variants may interact with DIL and DII, thus be involved in the development of cardiometabolic risk factors. If diabetic patients with Met alleles regulate dietary intakes, they have a protective opportunity to regulate their cardiometabolic markers. © The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society.
Related Docs
View other Related Docs
1. A Personalised Diet Approach Study: Interaction Between Ppar-Γ Pro12ala and Dietary Insulin Indices on Metabolic Markers in Diabetic Patients, Journal of Human Nutrition and Dietetics (2022)
2. Interaction Between Cetp Polymorphism and Dietary Insulin Index and Load in Relation to Cardiovascular Risk Factors in Diabetic Adults, Scientific Reports (2021)
3. Interactions of Bdnf Val66met and Dietary Indices in Relation to Metabolic Markers Among Patient With Type 2 Diabetes Mellitus: A Cross-Sectional Study, Journal of Health, Population and Nutrition (2023)
4. The Relationship Between Low-Carbohydrate Diet Score, Dietary Insulin Index and Load With Obesity in Healthy Adults, Eating and Weight Disorders (2022)
5. Dietary Insulin Index and Load and Cardiometabolic Risk Factors Among People With Obesity: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
6. Interaction Between Dietary Total Antioxidant Capacity and Bdnf Val66met Polymorphism on Lipid Profiles and Atherogenic Indices Among Diabetic Patients, Scientific Reports (2021)
7. Association Between Dietary Insulin Index and Load With Brain Derived Neurotrophic Factor, Adropin and Metabolic Health Status in Iranian Adults, Scientific Reports (2023)
8. Dietary Acid Load Modifies the Effects of Apoa2–265 T > C Polymorphism on Lipid Profile and Serum Leptin and Ghrelin Levels Among Type 2 Diabetic Patients, BMC Endocrine Disorders (2022)
Experts (# of related papers)
View all Related Experts
Parvane Saneei (14)
Farnaz Shahdadian (9)
Other Related Docs
9. Dietary Insulin Load and Index in Relation to Incident Gestational Diabetes Mellitus: A Prospective Cohort Study, Scientific Reports (2024)
10. Dietary Glycemic Index and Insulin Index in Association With Incident Type 2 Diabetes Mellitus in Adults, British Journal of Nutrition (2025)
11. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
12. Association of Dietary Insulin Index and Dietary Insulin Load With Metabolic Health Status in Iranian Overweight and Obese Adolescents, Frontiers in Nutrition (2022)
13. Associations Between Dietary Insulin Load With Cardiovascular Risk Factors and Inflammatory Parameters in Elderly Men: A Cross-Sectional Study, British Journal of Nutrition (2019)
14. Association Between Dietary Insulin Index and Load With Obesity in Adults, European Journal of Nutrition (2020)
15. Dietary Acid Load Adopts the Effect of Apob Ins/Del Genetic Variant (Rs11279109) on Obesity Trait, Cardiovascular Markers, Lipid Profile, and Serum Leptin Level Among Patients With Diabetes: A Cross-Sectional Study, Scientific Reports (2024)
16. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)
17. The Association Between Dietary Insulin Index and Load With Mental Health, BMC Psychology (2022)
18. Association of Brain-Derived Neurotrophic Factor Gene Polymorphisms With Body Mass Index: A Systematic Review and Meta-Analysis, Advances in Medical Sciences (2018)
19. Dietary Insulin Index and Insulin Load in Relation to Glioma: Findings From a Case–Control Study, Nutritional Neuroscience (2021)
20. Interaction Between the Dietary Indices and Ppar-Γ Pro12ala Gene Variants on Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus, International Journal of Clinical Practice (2021)
21. Carbohydrate Quality Indices and Colorectal Cancer Risk: A Case-Control Study, BMC Cancer (2023)
22. Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphism Rs7903146 Is Associated With Lipid Profile and Risk of Cardiovascular Disease Inmetabolic Syndrome Subjects, Journal of Biology and Today's World (2016)
23. Dietary Insulinemic Potential, Sleep Quality and Quantity in Iranian Adults: Yazd Health Study and Tamyz Study, BMC Nutrition (2023)
24. The Hhex Rs1111875a/G Gene Polymorphism Is Associated With Susceptibility to Type 2 Diabetes in the Iranian Population, Molecular Biology (2015)
25. Variants in the Ppargc1a Gene May Influence the Effect of Fat Intake on Resting Metabolic Rate in Obese Women, Lipids (2018)
26. Association of a Common Variant in Tcf7l2 Gene With Type 2 Diabetes Mellitus in a Persian Population, Clinical and Experimental Medicine (2012)
27. The Association Between Dietary Insulin Index and Load With Gastric Cancer in Afghanistan, Nutrition and Cancer (2022)
28. Dietary Acid Load and Its Interaction With Cetp Taqb1 Polymorphisms on Lipid Profile Among Patients With Type 2 Diabetes Mellitus, BMC Endocrine Disorders (2023)
29. Interaction Between Cetp Taq1b Polymorphism and Hei, Dqi and Dpi on Metabolic Biomarkers in Patients With Type 2 Diabetes, Journal of Human Nutrition and Dietetics (2022)
30. Lipid Regulatory Genes Polymorphism in Children With and Without Obesity and Cardiometabolic Risk Factors: The Caspian-Iii Study, Journal of Research in Medical Sciences (2018)
31. Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Biochemical and Anthropometric Factors in Type 2 Diabetes Mellitus, Scientific Reports (2021)
32. Brain-Derived Neurotrophic Factor Gene Val66met Polymorphism and Risk of Schizophrenia: A Meta-Analysis of Case–Control Studies, Cellular and Molecular Neurobiology (2016)
33. Association of Gstt1 and Gstm1 Polymorphisms With Blood Pressure: A Bayesian Modeling of Continuous Data, Journal of Research in Medical Sciences (2014)
34. The Effects of Aerobic Exercise on Liver Function, Insulin Resistance, and Lipid Profiles in Prediabetic and Type 2 Diabetic Mice, Physiology and Behavior (2023)
35. The Association Between Dietary Diversity Score and Food Insecurity and Novel Cardiovascular Risk Factors in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2025)
36. A Nutrigenetic Approach to Investigate Apob Ecor1 Polymorphism-Dietary Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in Adults With Dyslipidemic Type 2 Diabetes, Lifestyle Genomics (2023)
37. Nutrient Patterns in Relation to Metabolic Health Status and Serum Levels of Brain-Derived Neurotrophic Factor (Bdnf) and Adropin in Adults, Scientific Reports (2024)
38. Polyphenols for Diabetes Associated Neuropathy: Pharmacological Targets and Clinical Perspective, DARU, Journal of Pharmaceutical Sciences (2019)
39. Dietary Intake of Methyl Donor Nutrients in Relation to Metabolic Health Status, Serum Levels of Brain-Derived Neurotrophic Factor and Adropin, Clinical Nutrition (2024)
40. Association Between Methyl Donor Nutrients And Metabolic Health Status in Overweight and Obese Adolescents, Scientific Reports (2022)
41. People With Impaired Glucose Tolerance and Impaired Fasting Glucose Are Similarly Susceptible to Cardiovascular Disease: A Study in First-Degree Relatives of Type 2 Diabetic Patients, Annals of Nutrition and Metabolism (2010)
42. Should the First Degree Relatives of Type 2 Diabetic Patients With Isolated Impaired Fasting Glucose Be Considered for a Diabetes Primary Prevention Program?, Journal of Research in Medical Sciences (2010)
43. Adherence to Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay Diet in Relation to Serum Brain-Derived Neurotrophic Factor Concentrations and Metabolic Health Status in Adults, Current Developments in Nutrition (2024)
44. Joint Effects of Paraoxonase 1 Rs662 Polymorphism and Vitamins C/E Intake on Coronary Artery Disease Severity (Gensini and Syntax Scores) and Lipid Profile in Patients Undergoing Coronary Angiography, Frontiers in Nutrition (2023)
45. Weight Status of the First-Degree Relatives of Patients With Type 2 Diabetes Based on the Glucose Tolerance Test, Journal of Research in Medical Sciences (2012)
46. Association of Dietary Fatty Acids With Metabolic Syndrome Indices in Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2016)
47. Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different Fto Genotypes, Endocrinology, Diabetes and Metabolism (2024)
48. Joint Effects of Dietary Patterns and Paraoxonase1 Rs662 Polymorphism on Coronary Artery Disease Severity (Gensini and Syntax Scores) and Its Risk Factors in Adults Undergoing Angiography, Molecular Nutrition and Food Research (2024)
49. Dietary Acid Load and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Observational Studies, Public Health Nutrition (2019)
50. Dietary Energy Density, Metabolic Parameters, and Blood Pressure in a Sample of Adults With Obesity, BMC Endocrine Disorders (2023)