Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults Publisher



Hajhashemy Z1, 2 ; Lotfi K3 ; Shahdadian F2, 4 ; Rouhani P1, 2 ; Heidari Z5 ; Saneei P1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Frontiers in Nutrition Published:2022


Abstract

Background: The evidence about the relation of the insulinemic potential of food with visceral obesity and brain-derived neurotrophic factor (BDNF) was limited. We aimed to investigate the relation of dietary insulin index (DII) and dietary insulin load (DIL) with hypertriglyceridemic waist phenotype (HTGW) and serum BDNF in Iranian adults. Methods: This cross-sectional study included 528 middle-aged adults (45.6% women), using a multistage cluster random-sampling method. Dietary intakes were assessed using a validated semi-quantitative 168-item food frequency questionnaire. Blood samples were collected after 12 h of fasting for assessing the serum BDNF and triglyceride concentrations. HTGW was defined as triacylglycerol ≥ 150 mg/dL plus enlarged waist circumference. The values less than the first decile of serum BDNF were considered as the low level. Results: Individuals in the top tertile of DIL, in comparison to those in the bottom tertile, had higher odds of HTGW in both crude (OR = 1.96, 95% CI: 1.14–3.37) and fully adjusted model (OR = 6.10, 95% CI: 1.58–23.53). However, the relation between DII and odds of HTGW was statistically insignificant in crude (OR = 1.30, 95% CI: 0.78–2.16) and maximally adjusted model (OR = 1.25, 95% CI: 0.65–2.40). After considering confounders, participants in the top tertile of DIL had marginally higher odds of having low BDNF values (OR = 2.00, 95% CI: 0.95–4.21). Nevertheless, the association between DII and odds of low BDNF values was statistically insignificant. Conclusion: This population-based study demonstrated that adults with higher DIL had significantly higher chance of HTGW phenotype and slightly higher chance for low BDNF level. DII was not associated with HTGW phenotype or BDNF values. Copyright © 2022 Hajhashemy, Lotfi, Shahdadian, Rouhani, Heidari and Saneei.
Related Docs
View other Related Docs
1. Association Between Dietary Insulin Index and Load With Brain Derived Neurotrophic Factor, Adropin and Metabolic Health Status in Iranian Adults, Scientific Reports (2023)
2. Dietary Insulin Index and Load and Cardiometabolic Risk Factors Among People With Obesity: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
3. Association of Dietary Insulin Index and Dietary Insulin Load With Metabolic Health Status in Iranian Overweight and Obese Adolescents, Frontiers in Nutrition (2022)
4. Association Between Dietary Insulin Index and Load With Obesity in Adults, European Journal of Nutrition (2020)
5. The Relationship Between Low-Carbohydrate Diet Score, Dietary Insulin Index and Load With Obesity in Healthy Adults, Eating and Weight Disorders (2022)
6. Dietary Phytochemical Index in Relation to Metabolic Health Status, Serum Adropin, and Brain-Derived Neurotrophic Factor Levels in Adults, Current Developments in Nutrition (2024)
7. Nutrient Patterns in Relation to Metabolic Health Status and Serum Levels of Brain-Derived Neurotrophic Factor (Bdnf) and Adropin in Adults, Scientific Reports (2024)
8. Diet in Relation to Metabolic, Sleep and Psychological Health Status (Dimets): Protocol for a Cross-Sectional Study, BMJ Open (2023)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (68)
Nizal Sarrafzadegan (60)
Other Related Docs
9. Adherence to Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay Diet in Relation to Serum Brain-Derived Neurotrophic Factor Concentrations and Metabolic Health Status in Adults, Current Developments in Nutrition (2024)
10. Ultra-Processed Foods Intake in Relation to Metabolic Health Status, Serum Brain-Derived Neurotrophic Factor and Adropin Levels in Adults, Nutrition Journal (2024)
11. Dietary Glycemic Index and Insulin Index in Association With Incident Type 2 Diabetes Mellitus in Adults, British Journal of Nutrition (2025)
12. The Association Between Dietary Insulin Index and Load With Mental Health, BMC Psychology (2022)
13. Carbohydrate Quality Indices and Colorectal Cancer Risk: A Case-Control Study, BMC Cancer (2023)
14. Dietary Intake of Methyl Donor Nutrients in Relation to Metabolic Health Status, Serum Levels of Brain-Derived Neurotrophic Factor and Adropin, Clinical Nutrition (2024)
15. A Personalised Diet Approach Study: Interaction Between Ppar-Γ Pro12ala and Dietary Insulin Indices on Metabolic Markers in Diabetic Patients, Journal of Human Nutrition and Dietetics (2022)
16. Dietary Insulin Load and Index in Relation to Incident Gestational Diabetes Mellitus: A Prospective Cohort Study, Scientific Reports (2024)
17. Associations Between Dietary Insulin Load With Cardiovascular Risk Factors and Inflammatory Parameters in Elderly Men: A Cross-Sectional Study, British Journal of Nutrition (2019)
18. Total Fat and Omega-3 Fatty Acids Intake in Relation to Serum Brain-Derived Neurotrophic Factor (Bdnf) Levels and Psychological Disorders in Iranian Adults, Scientific Reports (2023)
19. Interactions of Dietary Insulin Index and Dietary Insulin Load With Brain-Derived Neurotrophic Factor (Bdnf) Val66met Polymorphism in Relation to Cardiometabolic Markers in Iranian Diabetic Patients: A Cross-Sectional Study, British Journal of Nutrition (2022)
20. Interaction Between Cetp Polymorphism and Dietary Insulin Index and Load in Relation to Cardiovascular Risk Factors in Diabetic Adults, Scientific Reports (2021)
21. Association Between Dietary Insulin Index and Load and Psychological Disorders, British Journal of Nutrition (2020)
22. A Systematic Review and Meta-Analysis of Association Between Brain-Derived Neurotrophic Factor and Type 2 Diabetes and Glycemic Profile, Scientific Reports (2021)
23. The Association Between Dietary Insulin Index and Load With Gastric Cancer in Afghanistan, Nutrition and Cancer (2022)
24. Dietary Energy Density, Metabolic Parameters, and Blood Pressure in a Sample of Adults With Obesity, BMC Endocrine Disorders (2023)
25. Dietary Insulin Index and Insulin Load in Relation to Glioma: Findings From a Case–Control Study, Nutritional Neuroscience (2021)
26. Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension, Endocrinology and Metabolism (2017)
27. Utility of Hypertriglyceridemic Waist Phenotype for Predicting Incident Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Journal of Diabetes Investigation (2016)
28. Association of Major Dietary Patterns With Advanced Glycation End Products and High-Sensitivity C-Reactive Protein in People With Type 1 Diabetes Mellitus, Nutrition Journal (2023)
29. Association of Dietary Total Antioxidant Capacity to Anthropometry in Healthy Women: A Cross-Sectional Study, Nutrition (2020)
30. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
31. Association Between Type 2 Diabetes and Different Types of Dietary Fats: A Case-Control Study, Clinical Nutrition ESPEN (2023)
32. Dietary and Lifestyle Indices for Hyperinsulinemia and Colorectal Cancer Risk: A Case-Control Study, BMC Gastroenterology (2023)
33. Legumes and Nuts Intake in Relation to Metabolic Health Status, Serum Brain Derived Neurotrophic Factor and Adropin Levels in Adults, Scientific Reports (2023)
34. Association Between Mediterranean Dietary Pattern With Sleep Duration, Sleep Quality and Brain Derived Neurotrophic Factor (Bdnf) in Iranian Adults, Scientific Reports (2023)
35. Patterns of Dietary Habits in Relation to Obesity in Iranian Adults, European Journal of Nutrition (2016)
36. Association of Dietary Fatty Acids With Metabolic Syndrome Indices in Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2016)
37. Association Between Adherence to Mind Diet and General and Abdominal Obesity: A Cross-Sectional Study, Nutrition Journal (2020)
38. Comparison of Different Obesity Indices for Predicting Incident Hypertension, High Blood Pressure and Cardiovascular Prevention (2017)
39. Association Between Plant-Based Diets and Metabolic Syndrome in Obese Adults From Iran: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
40. Identification of Diet-Disease Relations Through Dietary Pattern Approach: A Review, Journal of Research in Medical Sciences (2008)
41. Association Between Ultra-Processed Foods Intake With Lipid Profile: A Cross-Sectional Study, Scientific Reports (2023)
42. Dietary Glycemic Index and Glycemic Load in Association With Sleep Duration: Yahs-Tamyz and Shahedieh Observational Studies, Clinical Nutrition ESPEN (2021)
43. Dietary Insulinemic Potential, Sleep Quality and Quantity in Iranian Adults: Yazd Health Study and Tamyz Study, BMC Nutrition (2023)
44. White Rice Consumption and Cvd Risk Factors Among Iranian Population, Journal of Health, Population and Nutrition (2013)
45. Association of Combined Healthy Lifestyle With General and Abdominal Obesity, Frontiers in Nutrition (2023)
46. Interaction Between Dietary Total Antioxidant Capacity and Bdnf Val66met Polymorphism on Lipid Profiles and Atherogenic Indices Among Diabetic Patients, Scientific Reports (2021)
47. Dietary Phytochemical Index and Its Relationship With Diabetic Sensorimotor Polyneuropathy: A Case-Control Study, Scientific Reports (2024)
48. Dietary and Non-Dietary Determinants of Central Adiposity Among Tehrani Women, Public Health Nutrition (2008)
49. Effect of Potato Consumption As a High Glycemic Index Food on Pre-Diabetes Adult Patients, Pakistan Journal of Medical Sciences (2013)
50. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)