Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis

Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis Publisher Pubmed

Derakhshan A^{1, 2} ; Mannisto T³ ; Chen L⁴ ; Osinga JAJ^{1, 2} ; Ashoor G⁵ ; Lu X⁴ ; Bliddal S^{6, 7} ; Tao FB^{8, 9} ; Brown SJ¹⁰ ; Vaidya B¹¹ ; Hattersley AT¹² ; Itoh S¹³ ; Popova PV^{14, 15} ; Aminorroaya A¹⁶ Show All Authors

Derakhshan A^{1, 2}
Mannisto T³
Chen L⁴
Osinga JAJ^{1, 2}
Ashoor G⁵
Lu X⁴
Bliddal S^{6, 7}
Tao FB^{8, 9}
Brown SJ¹⁰
Vaidya B¹¹
Hattersley AT¹²
Itoh S¹³
Popova PV^{14, 15}
Aminorroaya A¹⁶
Kishi R¹³
Kianpour M¹⁶
Vasukova EA¹⁴
Lopezbermejo A^{17, 18}
Oken E¹⁹
Chatzi L²⁰
Vafeiadi M²¹
Bramer WM²²
Bassols J²³
Lertxundi A^{24, 25, 26}
Fernandezsomoano A^{24, 27, 28}
Carrasco P^{29, 30}
Auvinen J³¹
Huang K^{32, 33}
Feldtrasmussen U^{6, 7}
Grineva EN¹⁴
Alexander EK³⁴
Pearce EN³⁵
Chaker L^{1, 2}
Walsh JP^{10, 36}
Peeters RP^{1, 2}
Guxens M^{24, 37, 38, 39}
Suvanto E⁴⁰
Nicolaides KH⁴¹
Korevaar TIM^{1, 2}

Show Affiliations

1. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 GD, Netherlands
2. Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, 3015 GD, Netherlands
3. Northern Finland Laboratory Center Nordlab and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, 90570, Finland
4. Department of Endocrinology, Rui’an Center, The Chinese, American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China
5. Harris Birthright Research Center for Fetal Medicine, King’s College Hospital, London, SE5 9RS, United Kingdom
6. Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 2100, Denmark
7. Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, 1172, Denmark
8. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui, Hefei, 230032, China
9. Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui, Hefei, 230032, China
10. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Perth, 6009, WA, Australia
11. Department of Endocrinology, Royal Devon University Hospital NHS Foundation Trust, University of Exeter Medical School, Exeter, EX1 2LU, United Kingdom
12. Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, EX1 2LU, United Kingdom
13. Center for Environmental and Health Sciences, Hokkaido University, Hokkaido, Sapporo, 060-0808, Japan
14. World-Class Research Center for Personalized Medicine, Institute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, 197341, Russian Federation
15. Department of Internal Diseases and Endocrinology, St.Petersburg Pavlov State Medical University, Saint Petersburg, 197341, Russian Federation
16. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, 81745-33871, Iran
17. Pediatric Endocrinology Research Group, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta Hospital, Girona, 17007, Spain
18. Departament de Ciencies Mediques, Universitat de Girona, Girona, 17007, Spain
19. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Boston, 02215, MA, United States
20. Department of Population and Public Health Sciences UoSC, Keck School of Medicine, Los Angeles, 90033, CA, United States
21. Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, 700 13, Greece
22. Medical Library, Erasmus University Medical Centre, Rotterdam, 3015, Netherlands
23. Maternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta Hospital, Girona, 17007, Spain
24. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain
25. Department of Preventive Medicine and Public Health, University of Basque Country, Leioa, 48940, Spain
26. BIODONOSTIA Health Research Institute, San Sebastian, 20014, Spain
27. Unit of Molecular Cancer Epidemiology, University Institute of Oncology of the Principality of Asturias (IUOPA), Department of Medicine, University of Oviedo, Oviedo, Asturias, 33006, Spain
28. Institute of Health Research of the Principality of Asturias (ISPA), Oviedo, 33006, Spain
29. Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de Valencia, Valencia, 46020, Spain
30. Department of Medicine, Universitat Jaume I, Castellon de la Plana, 12071, Spain
31. Medical Research Center Oulu, Oulu University Hospital, Center for Life Course Health Research, University of Oulu, Oulu, 90570, Finland
32. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui, 230032, China
33. Scientific Research Center in Preventive Medicine, School of Public Health, Anhui Medical University, Anhui, 230032, China
34. Division of Endocrinology, Hypertension and Diabetes, Brigham and Women’s Hospital, Harvard Medical School, Boston, 02215, MA, United States
35. Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, 02215, MA, United States
36. Medical School, University of Western Australia, Crawley, 6009, WA, Australia
37. ISGlobal, Barcelona, 08003, Spain
38. Pompeu Fabra University, Barcelona, 08002, Spain
39. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Sophia Children’s Hospital, Rotterdam, 3012, Netherlands
40. Department of Obstetrics and Gynecology, Medical Research Center Oulu, University of Oulu, Oulu, 90570, Finland
41. Department of Women and Children’s Health, Faculty of Life Sciences, Medicine King’s College London, London, WC2R 2LS, United Kingdom

Source: Journal of Clinical Endocrinology and Metabolism Published:2024

Abstract

Context: Triiodothyronine (T3) is the bioactive form of thyroid hormone. In contrast to thyroid-stimulating hormone and free thyroxine, we lack knowledge on the association of gestational T3 with adverse obstetric outcomes. Objective: To investigate the associaiton of gestational free or total T3 (FT3 or TT3) with adverse obstetric outcomes. Methods: We collected individual participant data from prospective cohort studies on gestational FT3 or TT3, adverse obstetric outcomes (preeclampsia, gestational hypertension, preterm birth and very preterm birth, small for gestational age [SGA], and large for gestational age [LGA]), and potential confounders. We used mixed-effects regression models adjusting for potential confounders. Results: The final study population comprised 33 118 mother–child pairs of which 27 331 had data on FT3 and 16 164 on TT3. There was a U-shaped association of FT3 with preeclampsia (P = .0069) and a J-shaped association with the risk of gestational hypertension (P = .029). Higher TT3 was associated with a higher risk of gestational hypertension (OR per SD of TT3 1.20, 95% CI 1.08 to 1.33; P = .0007). A lower TT3 but not FT3 was associated with a higher risk of very preterm birth (OR 0.72, 95% CI 0.55 to 0.94; P = .018). TT3 but not FT3 was positively associated with birth weight (mean difference per 1 SD increase in TT3 12.8, 95% CI 6.5 to 19.1 g, P < .0001) but there was no association with SGA or LGA. Conclusion: This study provides new insights on the association of gestational FT3 and TT3 with major adverse pregnancy outcomes that form the basis for future studies required to elucidate the effects of thyroid function on pregnancy outcomes. Based on the current study, routine FT3 or TT3 measurements for the assessment of thyroid function during pregnancy do not seem to be of added value in the risk assessment for adverse outcomes. © The Author(s) 2023.

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Style	Citing Format
MLA	Derakhshan A, et al.. "Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis." Journal of Clinical Endocrinology and Metabolism, vol. 109, no. 3, 2024, pp. e1290-e1298.
APA	Derakhshan A, Mannisto T, Chen L, Osinga JAJ, Ashoor G, Lu X, Bliddal S, Tao FB, Brown SJ, Vaidya B, Hattersley AT, Itoh S, Popova PV, Aminorroaya A, Kishi R, Kianpour M, Vasukova EA, Lopezbermejo A, Oken E, ... Korevaar TIM (2024). Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis. Journal of Clinical Endocrinology and Metabolism, 109(3), e1290-e1298.
Chicago	Derakhshan A, Mannisto T, Chen L, Osinga JAJ, Ashoor G, Lu X, Bliddal S, et al.. "Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis." Journal of Clinical Endocrinology and Metabolism 109, no. 3 (2024): e1290-e1298.
Harvard	Derakhshan A et al. (2024) 'Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis', Journal of Clinical Endocrinology and Metabolism, 109(3), pp. e1290-e1298.
Vancouver	Derakhshan A, Mannisto T, Chen L, Osinga JAJ, Ashoor G, Lu X, et al.. Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis. Journal of Clinical Endocrinology and Metabolism. 2024;109(3):e1290-e1298.
BibTex	@article{ author = {Derakhshan A and Mannisto T and Chen L and Osinga JAJ and Ashoor G and Lu X and Bliddal S and Tao FB and Brown SJ and Vaidya B and Hattersley AT and Itoh S and Popova PV and Aminorroaya A and Kishi R and Kianpour M and Vasukova EA and Lopezbermejo A and Oken E and Chatzi L and Vafeiadi M and Bramer WM and Bassols J and Lertxundi A and Fernandezsomoano A and Carrasco P and Auvinen J and Huang K and Feldtrasmussen U and Grineva EN and Alexander EK and Pearce EN and Chaker L and Walsh JP and Peeters RP and Guxens M and Suvanto E and Nicolaides KH and Korevaar TIM}, title = {Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis}, journal = {Journal of Clinical Endocrinology and Metabolism}, volume = {109}, number = {3}, pages = {e1290-e1298}, year = {2024} }
RIS	TY - JOUR AU - Derakhshan A AU - Mannisto T AU - Chen L AU - Osinga JAJ AU - Ashoor G AU - Lu X AU - Bliddal S AU - Tao FB AU - Brown SJ AU - Vaidya B AU - Hattersley AT AU - Itoh S AU - Popova PV AU - Aminorroaya A AU - Kishi R AU - Kianpour M AU - Vasukova EA AU - Lopezbermejo A AU - Oken E AU - Chatzi L AU - Vafeiadi M AU - Bramer WM AU - Bassols J AU - Lertxundi A AU - Fernandezsomoano A AU - Carrasco P AU - Auvinen J AU - Huang K AU - Feldtrasmussen U AU - Grineva EN AU - Alexander EK AU - Pearce EN AU - Chaker L AU - Walsh JP AU - Peeters RP AU - Guxens M AU - Suvanto E AU - Nicolaides KH AU - Korevaar TIM TI - Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis JO - Journal of Clinical Endocrinology and Metabolism VL - 109 IS - 3 SP - e1290 EP - e1298 PY - 2024 ER -

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