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Association Between Dietary Phytochemical Index and Neonatal Thyroid Function Publisher Pubmed



Hashemi Dehkordi V1 ; Khoshhali M2 ; Heidaribeni M3 ; Hashemi Dehkordi E4 ; Hashemipour M4, 5 ; Mostofizadeh N1 ; Daniali SS2 ; Kelishadi R2
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Endocrinology Endocrine and Metabolism Research Center Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatrics Child Growth and Development Research Center Research Institute for Primordial Prevention of Non-Communicable Disease Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Nutrition Child Growth and Development Research Center Research Institute for Primordial Prevention of Non-Communicable Disease Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pediatric Endocrinology Child Growth and Development Research Centre Research Institute for Primordial Prevention of Non-Communicable Disease Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Metabolic Liver Diseases Research Center Imam Hossein Children's Hospital Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of pregnancy Published:2024


Abstract

Background: Thyroid hormones regulate fetal growth and differentiation of several tissues. Maternal dietary patterns may be correlated with changes in the level of neonatal thyroid-stimulating hormone (TSH). We hypothesized that since maternal nutrition affects birth weight and offspring growth, it may also impact endocrine patterns in offspring. This study is aimed at assessing the relationship between maternal dietary phytochemical index (DPI) in the first trimester of pregnancy and neonatal cord blood thyroid hormone levels. Methods: This cross-sectional study is a substudy of a birth cohort. Overall, 216 mothers, aged 16-45 years, were recruited in their first trimester of pregnancy. To calculate DPI, the daily energy percentage of phytochemical-rich foods was divided by the total daily energy intake. At delivery time, TSH and free thyroxine (FT4) levels were measured in cord blood samples using chemiluminescence immunoassay. Results: The mean (standard deviation (SD)) age of mothers was 29.56 (5.50) years, and 47% of newborns were girls. The mean (SD) of DPI in the first, second, third, and fourth quartiles was 25.03 ± 4.67, 33.87 ± 2.18, 40.64 ± 2.10, and 51.17 ± 4.98, respectively. There was not any significant correlation between DPI score with cord serum TSH and FT4 levels in crude and adjusted analysis. Conclusion: No significant relationship between maternal DPI with cord serum TSH and FT4 levels was shown. Limited experience exists about the effect of maternal diet quality indices on neonatal thyroid function, and further studies are needed in this regard. Copyright © 2024 Vida Hashemi Dehkordi et al.
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