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Effect of Maternal Triclosan Exposure on Neonatal Thyroid-Stimulating Hormone Levels: A Cross-Sectional Study Publisher Pubmed



Attarian E1, 2, 3 ; Ebrahimpour K2, 3 ; Maracy M3, 4 ; Daniali SS5 ; Shoshtariyeganeh B3 ; Moazeni M1, 2 ; Ebrahimi A2, 3 ; Kelishadi R5
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, 81676-36954, Iran
  5. 5. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Environmental and Public Health Published:2022


Abstract

Objective. This study is aimed at assessing the relationship between maternal urinary triclosan (uTCS) exposure and the thyroid-stimulating hormone (TSH) level of infant cord blood. Methods. This cross-sectional study was carried out in 2019-2020 in Isfahan, Iran, and 99 pregnant women participated in the study. Urine samples were collected after the 28th week of pregnancy, and the concentration of TCS was measured using GC/MS. The cord blood levels of TSH (CBL-TSH) were measured. The association between uTCS and CBL-TSH was examined based on the general linear model. Results. TCS was detected (≥0.01 ng/mL) in 100% of the urine samples, with the interquartile range (25%-75%) of uTCS levels 0.6-6.23 μg/g Cr. uTCS was not associated with CBL-TSH after adjustment for covariates. A significant relationship was observed between CBL-TSH of neonates born to mothers who had given birth only once compared to mothers who had given birth twice or more times. Conclusions. Maternal exposure to TCS did not affect the infant CBL-TSH. However, the high concentrations of TCS in maternal urinary samples indicate the necessity of more precise regulations to decrease the use of this chemical in the industry and increase public awareness about using TCS-free compounds. © 2022 Elham Attarian et al.
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