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A Review (Research and Patents) on Jasmonic Acid and Its Derivatives Publisher Pubmed



Ghasemi Pirbalouti A1, 2 ; Sajjadi SE3 ; Parang K4
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Plants, Shahrekord Branch, Islamic Azad University, Shahrekord, P.O. Box 166, Iran
  2. 2. Medicinal Plants Program, Stockbridge School of Agriculture, Massachusetts University, Amherst, MA, United States
  3. 3. Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, United States

Source: Archiv der Pharmazie Published:2014


Abstract

In medicinal chemistry there is a growing interest in using small molecules, including plant stress hormones. Jasmonic acid (JA) and its volatile methyl ester (MJ), collectively termed jasmonates, are lipid-derived cyclopentanone compounds that occur ubiquitously and exclusively in the plant kingdom. This review covers the synthesis, usage, and biological activities of JA and its derivatives. A brief overview of the available information on JA and its features is given, followed by a detailed review of JA and its derivatives as drugs and prodrugs; the properties in plants and the synthesis in recent patents are described. This review shows the direction of long-term drug/nutraceutical safety trials and provides insights for future research in this area. Research on JA continues to be of major interest. Recent innovations offer hope for the development of new therapeutics in related fields. It is anticipated that several analogs can be advanced to preclinical and clinical studies. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.