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New Jatrophane Diterpenes From Euphorbia Osyridea With Proapoptotic Effects on Ovarian Cancer Cells Publisher



Ghanadian M1 ; Saeidi H2 ; Aghaei M3 ; Rahiminejad MR2 ; Ahmadi E2 ; Ayatollahi SM4 ; Choudhary MI5, 6 ; Bahmani B3
Authors
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Authors Affiliations
  1. 1. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Iran
  2. 2. Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
  3. 3. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Iran
  5. 5. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan
  6. 6. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 214421, Saudi Arabia

Source: Phytochemistry Letters Published:2015


Abstract

Abstract A dichloromethane-acetone extract of Euphorbia osyridea Bioss. (Syn. Euphorbia lateriflora Schumach. & Thonn), a spurge endemic to Iran and West Africa, afforded three new jatrophane diterpenes belonging to the 2,3,5,7,8,9,14,15-octahydroxy-jatropha-6(17),11E-diene class along with three known triterpenes. Structures of these compounds were elucidated by spectroscopic methods, especially 2D NMR analyses. Biological effects of these compounds were analyzed by performing MTT and annexin V-FITC and PI staining assays against different cancer cell lines. Results showed that 2,3,5,7,8,9,14,15-octahydroxy-jatropha-6(17), 11E-diene derivatives (1-3) inhibit the cell proliferation through apoptosis in the Caov-4 and OVCAR-3 cancer cell lines. © 2015 Phytochemical Society of Europe.
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