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Ultra-Small But Ultra-Effective: Folic Acid-Targeted Gold Nanoclusters for Enhancement of Intracranial Glioma Tumors' Radiation Therapy Efficacy Publisher Pubmed



Kefayat A1 ; Ghahremani F2 ; Motaghi H3 ; Amouheidari A4
Authors
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Authors Affiliations
  1. 1. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Physics and Radiotherapy, Arak University of Medical Sciences, Arak, Iran
  3. 3. Department of Science, Farhangian University, Tehran, Iran
  4. 4. Department of Radiation Oncology, Isfahan Milad Hospital, Isfahan, Iran

Source: Nanomedicine: Nanotechnology, Biology, and Medicine Published:2019


Abstract

The aim of the present study is to investigate folic acid and BSA decorated gold nanoclusters (FA-AuNCs) effect on the enhancement of intracranial C6 glioma tumors radiation therapy (RT) efficacy. Inductively coupled plasma optical emission spectrometry (ICP-OES) measurements exhibited about 2.5 times more FA-AuNCs uptake by C6 cancer cells (32.8 ng/10 6 cells) than the normal cells. FA-AuNCs had significantly higher concentration in the brain tumors (8.1 μg/mg) in comparison with surrounding normal brain tissue (4.3 μg/mg). Moreover, FA-AuNCs exhibited dose enhancement factor (DEF) of 1.6. The glioma-bearing rats' survival times were almost doubled at radiation therapy + FA-AuNCs (25.0 ± 1.5 days) in comparison with no-treatment group (12.8 ± 0.7 days). The Ki-67 labeling index was 48.89% ± 9.93 for control, 29.98% ± 8.32 for RT, and 11.53% ± 7.65 for RT + FA-AuNCs. Therefore, FA-AuNCs can be effective radiosensitizers for intracranial glioma tumors RT. © 2018 Elsevier Inc.
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