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Intracranial Extramedullary Hematopoiesis in a Patient With Intermediate B-Thalassemia



Mahzuni P1 ; Tabesh H2 ; Mokhtari M1 ; Shekarchizadeh A2 ; Karami A1
Authors
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Authors Affiliations
  1. 1. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Extramedullary hematopoiesis refers to formation of hematopoietic tissue and it is a compensatory phenomen in hematologic disease like congenital hemolytic anemia, myelofibrosis, pernicious anemia & Bone marrow infiltration secondary to malignancies. It has been reported in many sites but the most common sites are liver, spleen & lymph node. Case Report: A 34-year-old man with intermediate B-thalassemia had chronic headache and progressive loss of visual function. In CT scan a lobulated, non homogenous hyperdense mass was seen in left occipital horn with massive surrounding edema. In histologic examination the presence of hematopoietic tissue in brain parenchyma was confirmed.
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