Comparison of the Effect of Topical Triamcinolone 0.1% Cream With Sulfur 2.0% Cream in the Treatment of Patients With Hand Eczema: A Randomized Controlled Trial Publisher Pubmed



Asilian A^{1, 2} ; Mohammadian P^{1, 2} ; Hosseini SM³ ; Heidaripour F⁴ ; Yekta A⁴ ; Nateghi MR⁵ Show Affiliations
Source: Journal of Cosmetic Dermatology Published:2024

Abstract

Background: Hand eczema (HE) is a common and heterogeneous condition. It has a wide range of etiologies and clinical manifestations. In this study the efficacy of triamcinolone 0.1% cream and sulfur 2% creams was compared in treating patients with HE. Methods: This randomized, triple-blind clinical trial was performed on 70 patients with HE (including 70 right and 70 left hands). In this study, two creams were used including triamcinolone 0.1% and sulfur 2.0%. Patients were treated with these creams twice a day (once in every 12 h) for 4 weeks. Follow-up was 4 weeks after treatment. Hand Eczema Severity Index (HECSI), itching, dryness, burning sensation, and erythema scores were collected three times during the study and compared between treatment regimens. Results: Findings showed that both triamcinolone (0.1%) and sulfur (2.0%) creams could significantly reduce the scores of HECSI, itching, dryness, burning sensation, and erythema, and the therapeutic effects lasted for at least 4 weeks after cessation of topical treatment. Conclusion: Topical sulfur cream (2.0%) is as effective as triamcinolone (0.1%) cream in treatment of HE without any prominent adverse reactions. © 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.