Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
High-Dose Topical Zinc Oxide Promotes Healing Indices of Pressure Ulcers: A Pilot Randomized Clinical Trial Publisher Pubmed



R Fadaei RAYEHE ; A Larkiharchegani AMIR ; F Sajedi FIROZEH ; S Pourmoslemi SHABNAM ; S Khazaei SALMAN ; S Shabib SOMAYEH
Authors

Source: International Journal of Lower Extremity Wounds Published:2025


Abstract

Objective: Pressure ulcers seriously affect patient quality of life. The present study aimed to investigate the therapeutic effects of 25% zinc oxide topical cream on treating stage I and II pressure ulcers. Methods: This randomized, double-blind clinical trial involved 60 patients, divided into the control group (n = 30) receiving a silver-containing dressing and the intervention group (n = 30) treated with 25% zinc oxide cream. Wound assessments were conducted on days 0, 7, and 14, alongside standard care. Results: In the end, the intervention group showed significantly higher rates of “partial healing” and “peri-wound erythema reduction” than the control group (pvalue < .05). The intervention group's partial healing increased from 3.33% (day 7) to 83.34% (day 14) (pvalue < .05), whereas the control group reached from 26.67% to 60%. On day 14, the intervention group experienced a 50% decrease in peri-wound erythema, while the control group only experienced a 9.5% reduction (pvalue < .05). Also, 3.33% of the intervention group achieved complete healing, while none in the control group did. Conclusion: The findings suggest that 25% zinc oxide cream may function as an effective and cost-efficient alternative to conventional dressings in managing stage I and II pressure ulcers. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. The Effect of Chamomile Cream on First-Degree Pressure Ulcer in Patients Admitted to Intensive Care Units; a Randomized Clinical Trial Study, Journal of Isfahan Medical School (2021)
2. The Effect of Topical Cow's Milk on the Healing of Diabetic Foot Ulcers: A Randomized Controlled Pilot Clinical Trial, International Journal of Lower Extremity Wounds (2024)
3. The Effectiveness of Pentoxifylline 10% Topical Gel on the Pressure Ulcer Healing: A Randomized Controlled Clinical Trial, International Journal of Lower Extremity Wounds (2025)
Experts (# of related papers)
View all Related Experts
Rasool Soltani (3)
Shadi Farsaei (2)
Other Related Docs
4. The Effect of Chamomile Cream on First-Degree Pressure Ulcer in Patients Admitted to Intensive Care Units; a Randomized Clinical Trial Study, Journal of Isfahan Medical School (2019)
5. Efficacy of Topical Atorvastatin for the Treatment of Pressure Ulcers: A Randomized Clinical Trial, Pharmacotherapy (2014)
6. Comparison of Topical Glyceryl Trinitrate With Dialtazem Ointment for Treatment of Chronic Anal Fissure. a Randomized Clinical Trial, Annali Italiani di Chirurgia (2009)
7. Evaluation of the Therapeutic Effect of Dressing Containing Silver (Ag Coat) in the Process of Healing Skin Blisters Caused by Limb Fractures: A Clinical Trial Study, BMC Surgery (2023)
8. Effect of Olive Oil in Preventing the Development of Pressure Ulcer Grade One in Intensive Care Unit Patients, International Journal of Preventive Medicine (2020)
9. Potential Therapeutic Effects of Topical Recombinant Human Erythropoietin on Burn Wound Healing: A Preliminary Randomized Double-Blind Controlled Clinical Trial, Burns (2024)
10. Topical Sucralfate for Treatment of Mucocutaneous Conditions: A Systematic Review on Clinical Evidences, Dermatologic Therapy (2022)
11. Effectiveness of Standard Treatment for Foot Ulcer of Diabetic Patients, Journal of Isfahan Medical School (2015)
12. Comparison of Topical Glyceryl Trinitrate With Diltiazem Ointment for the Treatment of Chronic Anal Fissure : A Randomized Clinical Trial, Acta Chirurgica Belgica (2009)
13. Comparison of Silver Nylon Wound Dressing and Silver Sulfadiazine in Partial Burn Wound Therapy, International Wound Journal (2013)
14. The Topical Formulation of Whey Protein for the Prevention of Pressure Ulcers in Critically Ill Patients: A Novel Intervention in a Randomized-Controlled Clinical Trial, Advanced Biomedical Research (2023)
15. The Effect of Henna (Lawsonia Inermis) on Preventing the Development of Pressure Ulcer Grade One in Intensive Care Unit Patients, International Journal of Preventive Medicine (2019)
16. Wound Dressing of Second Degree Burn by Chamomile Cream and Silver Sulfadiazine Cream; the Effects on Wound Healing Duration; a Triple Blind Rct, Journal of Medicinal Plants (2020)
17. The Effect of Plantago Major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial, International Journal of Lower Extremity Wounds (2024)
18. Risk Assessment and Prevention Program Impact on the Incidence of Pressure Ulcers in Intensive Care Unit, Research Journal of Medical Sciences (2019)
19. Topical Silver Sulfadiazine for the Prevention of Acute Dermatitis During Irradiation for Breast Cancer, Supportive Care in Cancer (2012)
20. Comparing the Efficacy of Emu Oil With Clotrimazole and Hydrocortisone in the Treatment of Seborrheic Dermatitis: A Clinical Trial, Journal of Research in Medical Sciences (2013)