The Antimicrobial and Healing Effect of Scrophularia Striata Boiss Hydroalcoholic Extract on First- and Second-Grade Pressure Wounds in Patients With Brain and Spinal Cord Injury: A Randomized Clinical Trial Publisher



Bagheri Z¹ ; Larkiharchegani A² ; Pourmoslemi S³ ; Niliahmadabadi A² ; Bakhtiari E⁴ ; Safarpour H⁵ ; Fathi Jouzdani A^{6, 7} ; Shamsizadeh M^{7, 8} Show Affiliations
Source: Evidence-based Complementary and Alternative Medicine Published:2022

Abstract

Introduction and Objectives. Pressure wound is one of the most common problems in patients with brain and spinal cord lesions leading to complications such as severe pain, infection, and frequent hospitalisation. The present study aimed to determine the restorative and antimicrobial effects of Scrophularia striata hydroalcoholic extract (SHE) on first- and second-grade pressure ulcers in patients with brain and spinal cord lesions. Materials and Methods. This double-blind clinical trial study was performed on grade 1 and 2 pressure wounds in 120 patients with cerebral-spinal cord lesions. The patients were randomly divided into four groups (n = 30). Topical treatments in all groups were performed twice a day. These groups included experiment 1 (SHE + phenytoin), experiment 2 (SHE + SHE), control (phenytoin + phenytoin), and placebo (eucerin + phenytoin). After evaluating the effect of SHE on wound healing, its antibacterial activity was determined by the standard agar well diffusion method. Results. Patients in each group in this study did not significantly differ in demographic and clinical variables. Complete wound healing by the 10th day of the intervention occurred in 63%, 100%, and 27% of patients in experimental 1, experimental 2, and control groups, respectively. In contrast, the placebo group had no complete wound healing until the 10th day. Topical application of SHE, twice a day in the experimental 2 groups, had a higher potency to heal wounds and reduce the duration of complete wound healing in patients compared with other groups. Conclusion. SHE, as a novel treatment option, has good potential to accelerate the healing of first- and second-degree pressure wounds in patients with brain-spinal cord injuries. © 2022 Zahra Bagheri et al.