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Effect of Probiotics and Synbiotics on Selected Anthropometric and Biochemical Measures in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Publisher Pubmed



Hadi A1 ; Moradi S2, 3 ; Ghavami A4 ; Khalesi S5 ; Kafeshani M6
Authors
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Authors Affiliations
  1. 1. Halal Research Center of IRI, FDA, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Physical Activity Research Group, Appleton Institute & School of Health Medical and Applied Sciences, Central Queensland University, Brisbane, Australia
  6. 6. School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: European Journal of Clinical Nutrition Published:2020


Abstract

This study aimed to systematically review randomized clinical trials (RCTs) to clarify the effects of pro-/synbiotic supplementation on anthropometric and biochemical measurements in women with polycystic ovary syndrome (PCOS). PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar were searched through September 2018. Eight RCTs (nine treatment arms) were included. Pro-/synbiotic supplementation significantly reduced fasting blood sugar (−2.52 mg/dl, 95% confidence interval (CI): −4.10 to −0.95), insulin (−2.27 µIU/mL, 95% CI: −3.40 to −1.14), homeostasis model assessment for insulin resistance index (−0.69, 95% CI: −0.98 to −0.40), C-reactive protein (−1.69 Hedges’, 95% CI: −3.00 to −0.38), and total testosterone (−0.12 ng/mL, 95% CI: −0.17 to −0.08) in women with PCOS. However, changes in the mean difference of weight and body mass index did not reach a statistically significant level. The findings suggest that pro-/synbiotic supplementation may improve glucose homeostasis parameters, hormonal, and inflammatory indices in women with PCOS. © 2019, Springer Nature Limited.
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