Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Inulin-Type Fructans With Different Degrees of Polymerization on Inflammation, Oxidative Stress and Endothelial Dysfunction in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial Publisher Pubmed



Ziaei R1 ; Shahshahan Z2 ; Ghasemitehrani H3 ; Heidari Z4 ; Ghiasvand R1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Fertility Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Clinical Endocrinology Published:2022


Abstract

Objective: Polycystic ovary syndrome (PCOS) is associated with several cardiovascular risk factors. Prebiotics were proposed to beneficially affect risk factors associated with metabolic disorders. The aim of this study was to investigate and compare the effects of inulin-type fructans (ITFs), as well-studied prebiotics, with different degrees of polymerization, on markers of inflammation, oxidative stress and endothelial dysfunction in PCOS patients. Design: A randomized, double-blind, placebo-controlled trial. Patients: Seventy-five PCOS women were randomly assigned to receive 10 g/day of either high-performance inulin (HPI) or oligofructose-enriched inulin (OEI) or placebo for 12 weeks. Measurements: Biochemical indices and blood pressure levelswere assessed before and after the intervention. Results: In the intent-to-treat analysis, high-sensitive C-reactive protein (hs-CRP) decreased in HPI and OEI groups, over the 12 weeks, and the changes were significant in the HPI group, compared to placebo (changes from baseline in the HPI group: −0.11 vs. placebo group: 0.004 mg/L [conversion factor to SI units (nmol/L): 9/5238]; p =.007). Serum levels of nitric oxide (NO) increased, and endothelin-1 and total oxidant status decreased in HPI and OEI groups, at the end of the trial; however, these changes were not significantly compared to placebo (p =.07,.36 and.22, respectively). No differences in systolic and diastolic blood pressure were found. Per-protocol analysis (n = 68) yielded consistent results for all endpoints, with the exception that the significant effect of ITFs on serum hs-CRP levels in the unadjusted ITT analysis became nonsignificant in the per-protocol analysis (p =.06). Conclusion: A 12-week supplementation with long-chain ITFs had favourable effects on inflammatory status among PCOS patients. © 2022 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Inulin-Type Fructans With Different Degrees of Polymerization Improve Insulin Resistance, Metabolic Parameters, and Hormonal Status in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Double-Blind, Placebo-Controlled Clinical Trial, Food Science and Nutrition (2024)
2. The Effects of Inulin Supplementation on Clinical Indices, Oxidative Stress and Inflammatory Biomarkers in Women With Migraine: A Double-Blind, Placebo-Controlled, Randomized Trial, Journal of Functional Foods (2024)
3. Comparison of the Impact of Intermittent Fasting Diet Alone or in Conjunction With Probiotic Supplementation Versus Calorie-Restricted Diet on Inflammatory, Oxidative Stress, and Antioxidant Capacity Biomarkers in Women With Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Trial, Journal of Research in Medical Sciences (2025)
4. The Effect of Synbiotics Supplementation on Anthropometric Indicators and Lipid Profiles in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Lipids in Health and Disease (2020)
5. Effects of Dash Diet on Lipid Profiles and Biomarkers of Oxidative Stress in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial, Nutrition (2014)
6. The Effects of Pro-, Pre-, and Synbiotics Supplementation on Polycystic Ovary Syndrome: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials, Frontiers in Nutrition (2023)
7. A Meta-Analysis of Effects of Vitamin E Supplementation Alone and in Combination With Omega-3 or Magnesium on Polycystic Ovary Syndrome, Scientific Reports (2022)
8. Effects of Probiotic Supplementation on Pancreatic Β‑Cell Function and C‑Reactive Protein in Women With Polycystic Ovary Syndrome: A Randomized Double‑Blind Placebo‑Controlled Clinical Trial, International Journal of Preventive Medicine (2015)
Experts (# of related papers)
View all Related Experts
Awat Feizi (10)
Gholamreza Askari (8)
Other Related Docs
9. Omega-3 and Vitamin E Co-Supplementation Can Improve Antioxidant Markers in Obese/Overweight Women With Polycystic Ovary Syndrome, International Journal for Vitamin and Nutrition Research (2020)
10. Effects of Probiotic Supplementation on Pancreatic Β‑Cell Function and C‑Reactive Protein in Women With Polycystic Ovary Syndrome: A Randomized Double‑Blind Placebo‑Controlled Clinical Trial, International Journal of Preventive Medicine (2015)
11. The Association Between Dietary Antioxidants, Oxidative Stress Markers, Abdominal Obesity and Poly-Cystic Ovary Syndrome: A Case Control Study, Journal of Obstetrics and Gynaecology (2020)
12. Omega-3 Supplementation Effects on Polycystic Ovary Syndrome Symptoms and Metabolic Syndrome, Journal of Research in Medical Sciences (2017)
13. Comparison of the Effects of Metformin, Flutamide Plus Oral Contraceptives, and Simvastatin on the Metabolic Consequences of Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2016)
14. Effect of Probiotics and Synbiotics on Selected Anthropometric and Biochemical Measures in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, European Journal of Clinical Nutrition (2020)
15. Effects of Ramadan Fasting on Glucose Homeostasis, Lipid Profiles, Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome in Kashan, Iran, Archives of Iranian Medicine (2015)
16. The Effects of Chromium Supplementation on Endocrine Profiles, Biomarkers of Inflammation, and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Biological Trace Element Research (2016)
17. Effects of Probiotic Supplementation on Hormonal and Clinical Outcomes of Women Diagnosed With Polycystic Ovary Syndrome: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Journal of Functional Foods (2022)
18. The Effect of Concentrated Pomegranate Juice on Biomarkers of Inflammation, Oxidative Stress, and Sex Hormones in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2023)
19. Calcium Plus Vitamin D Supplementation Influences Biomarkers of Inflammation and Oxidative Stress in Overweight and Vitamin D-Deficient Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Clinical Endocrinology (2015)
20. Cardiometabolic Risk Factors in Polycystic Ovary Syndrome, Pakistan Journal of Medical Sciences (2012)
21. Metabolic Response to Folate Supplementation in Overweight Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Molecular Nutrition and Food Research (2014)
22. The Effects of Curcumin Supplementation on Glycemic Status, Lipid Profile and Hs-Crp Levels in Overweight/Obese Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Complementary Therapies in Medicine (2019)
23. Blood Circulating Levels of Adipokines in Polycystic Ovary Syndrome Patients: A Systematic Review and Meta-Analysis, Reproductive Sciences (2021)
24. The Prevalence of Metabolic Syndrome and Insulin Resistance According to the Phenotypic Subgroups of Polycystic Ovary Syndrome in a Representative Sample of Iranian Females, Journal of Research in Medical Sciences (2011)
25. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
26. The Therapeutic Impact of Garlic (Allium Sativum) on Oxidative Stress Markers Among Polycystic Ovary Syndrome Patients: A Randomized, Double-Blinded Clinical Trial, International Journal of Preventive Medicine (2023)
27. Effect of Soy Phytoestrogen on Metabolic and Hormonal Disturbance of Women With Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2011)
28. Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? a Systematic Review, Probiotics and Antimicrobial Proteins (2017)
29. The Effect of Garlic (Allium Sativum) Supplementation on the Lipid Parameters and Blood Pressure Levels in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2021)
30. Clinical and Metabolic Responses to Magnesium Supplementation in Women With Polycystic Ovary Syndrome, Biological Trace Element Research (2020)
31. Effect of Metformin on Serum Ferritin Level in Women With Polycystic Ovary Syndrome, Iranian Red Crescent Medical Journal (2011)
32. Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10-18 Years Old, Clinical Chemistry (2007)
33. Effect of Hormone Replacement Therapy on Total Serum Anti-Oxidant Potential and Oxidized Ldl/ß2-Glycoprotein I Complexes in Postmenopausal Women, Endocrine Journal (2010)
34. Influence of Ω-3 Fatty Acid Eicosapentaenoic Acid on Igf-1 and Cox-2 Gene Expression in Granulosa Cells of Pcos Women, Iranian Journal of Reproductive Medicine (2015)
35. Effect of Multispecies Probiotic Supplements on Metabolic Profiles, Hs-Crp, and Oxidative Stress in Patients With Type 2 Diabetes, Annals of Nutrition and Metabolism (2013)
36. The Effect of Concentrated Pomegranate Juice Consumption on Risk Factors of Cardiovascular Diseases in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2021)
37. Diagnostic Value of Prostate-Specific Antigen in Women With Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2011)
38. The Effects of Probiotic Supplementation on Markers of Blood Lipids, and Blood Pressure in Patients With Prediabetes: A Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
39. Chromium Supplementation and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2017)
40. Dietary Pro-Oxidant Score (Pos) and Cardio-Metabolic Panel Among Obese Individuals: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
41. The Association Between Anthropometric Parameters and Cardiovascular Risk Indicators in Women With Polycystic Ovarian Syndrome, ARYA Atherosclerosis (2020)
42. The Prevalence of Polycystic Ovary Syndrome (Pcos) in Type 2 Diabetic Women in Reprodutive Ages, Iranian Journal of Diabetes and Lipid Disorders (2006)
43. Macronutrients and Postprandial Inflammation in the Metabolic Syndrome: Review of Current Evidence, Journal of Isfahan Medical School (2012)
44. The Effect of N-3 Polyunsaturated Fatty Acid Supplementation on Androgen Status in Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials, Hormone and Metabolic Research (2016)
45. Effect of Curcumin on Body Mass Index and Glycemic Indices in Females With Pcos: A Systematic Review and Meta-Analysis of Randomized Controlled Trial, Nutrition and Food Science (2022)
46. Circulating Resistin and Follistatin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, PLoS ONE (2021)
47. Global Prevalence of Polycystic Ovary Syndrome in Women Worldwide: A Comprehensive Systematic Review and Meta-Analysis, Archives of Gynecology and Obstetrics (2024)
48. Enzymatic Antioxidant System and Endothelial Function in Patients With Metabolic Syndrome, ARYA Atherosclerosis (2020)
49. Sex Based Levels of C-Reactive Protein and White Blood Cell Count in Subjects With Metabolic Syndrome: Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2013)
50. The Relationship Between Intake of Dairy Products and Polycystic Ovary Syndrome in Women Who Referred to Isfahan University of Medical Science Clinics in 2013, International Journal of Preventive Medicine (2014)