Effect of Hormone Replacement Therapy on Total Serum Anti-Oxidant Potential and Oxidized Ldl/ß2-Glycoprotein I Complexes in Postmenopausal Women Publisher Pubmed



Darabi M¹ ; Ani M¹ ; Movahedian A^{1, 2} ; Zarean E³ ; Panjehpour M¹ ; Rabbani M⁴
Source: Endocrine Journal Published:2010

Abstract

Oxidative stress and consequent oxidized lipoprotein production is thought to play a central role in both the initiation and progression of atherosclerosis. Oxidized low-density lipoprotein (oxLDL)/β2-glycoprotein I (β2GPI) complexes are etiologically important in the development of atherosclerosis. The aim of the present study was to investigate whether long-term treatment with conventional hormone replacement therapy (HRT) in postmenopausal women could affect total serum antioxidant capacity (TAC) and serum levels of oxLDL/β2GPI complexes. A total of 60 normolipidemic postmenopausal women treated with oral estrogen together with progestin therapy for 3 months were selected. TAC and serum levels of oxLDL/β2GPI complexes were measured at the beginning and end of the HRT. HRT led to a signifcant increase in TAC (15%, P=0.02) and a minor but statistically nonsignifcant decrease of oxLDL/β2GPI complexes (3%, P=0.30) when compared with the baseline control levels. There was also no signifcant association between TAC and oxLDL/β2GPI complexes changes related to HRT. This study indicates that, HRT in postmenopausal women leads to an increase in TAC without an equivalent change in serum levels of oxLDL/β2GPI complexes. It is concluded that benefcial effects of HRT could be explained, at least in part, by improving antioxidant status, but may not be directly associated with a change in oxidized lipoprotein production. ©The Japan Endocrine Society.