Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Serum Paraoxonase 1 Activity Is Associated With Fatty Acid Composition of High Density Lipoprotein Publisher Pubmed



Boshtam M1 ; Emami Razavi A2 ; Pourfarzam M3 ; Ani M3 ; Naderi GA1 ; Basati G4 ; Mansourian M5 ; Dinani NJ1 ; Asgary S6 ; Abdi S7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Iran National Tumor Bank, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Clinical Biochemistry, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran
  5. 5. Epidemiology and Biostatistics Department, Health School, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Apply Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Physics, Safadasht Branch, Islamic Azad University, Tehran, Iran

Source: Disease Markers Published:2013


Abstract

Introduction. Cardioprotective effect of high density lipoprotein (HDL) is, in part, dependent on its related enzyme, paraoxonase 1 (PON1). Fatty acid composition of HDL could affect its size and structure. On the other hand, PON1 activity is directly related to the structure of HDL. This study was designed to investigate the association between serum PON1 activity and fatty acid composition of HDL in healthy men. Methods. One hundred and forty healthy men participated in this research. HDL was separated by sequential ultracentrifugation, and its fatty acid composition was analyzed by gas chromatography. PON1 activity was measured spectrophotometrically using paraxon as substrate. Results. Serum PON1 activity was directly correlated with the amount of stearic acid and dihomo-gamma-linolenic acid (DGLA). PON1/HDL-C was directly correlated with the amount of miristic acid, stearic acid, and DGLA and was inversely correlated with total amount of ω6 fatty acids of HDL. Conclusion. The fatty acid composition of HDL could affect the activity of its associated enzyme, PON1. As dietary fats are the major determinants of serum lipids and lipoprotein composition, consuming some special dietary fatty acids may improve the activity of PON1 and thereby have beneficial effects on health. © 2013 Maryam Boshtam et al.
Related Docs
View other Related Docs
1. The Associations Between High-Density Lipoprotein Mean Particle Size and Its Fatty Acid Composition, Biomarkers in Medicine (2013)
2. Associations Between High Density Lipoprotein Mean Particle Size and Serum Paraoxonase--1 Activity, Journal of Research in Medical Sciences (2012)
3. Investigation of Membrane Fatty Acid Profiles in Erythrocytes of Patients With Stable Coronary Artery Disease, Journal of Clinical Lipidology (2016)
4. Fatty Acid Composition of Hdl Phospholipids and Coronary Artery Disease, Journal of Clinical Lipidology (2009)
5. Joint Effects of Paraoxonase 1 Rs662 Polymorphism and Vitamins C/E Intake on Coronary Artery Disease Severity (Gensini and Syntax Scores) and Lipid Profile in Patients Undergoing Coronary Angiography, Frontiers in Nutrition (2023)
6. Evaluation of Relationship Between Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients, ARYA Atherosclerosis (2014)
7. Association of the Total Cholesterol Content of Erythrocyte Membranes With the Severity of Disease in Stable Coronary Artery Disease, Cholesterol (2014)
8. Anti-Hyperelipidemic Effects of Sumac (Rhus Coriaria L.): Can Sumac Strengthen Anti-Hyperlipidemic Effect of Statins?, Der Pharmacia Lettre (2016)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (23)
Nizal Sarrafzadegan (22)
Other Related Docs
9. Decreased Na+/K+-Atpase Activity and Altered Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes of Metabolic Syndrome Patients With Coronary Artery Disease, Annals of Nutrition and Metabolism (2019)
10. Ldl Fatty Acids Composition As a Risk Biomarker of Cardiovascular Disease, Artery Research (2017)
11. Evaluation of the Effects of Cucumis Sativus Seed Extract on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Journal of Food Science (2017)
12. Epidemiologic Evidence on Serum Adiponectin Level and Lipid Profile, International Journal of Preventive Medicine (2013)
13. Is Any Association Between Alternate Healthy Eating Index (Ahei) With Lipid Profile and Liver Enzymes? a Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2021)
14. Changes in Serum Lipid Profile of Obese or Overweight Children and Adolescents Following a Lifestyle Modification Course, ARYA Atherosclerosis (2012)
15. Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects With Cardiovascular Disease Risk Factors, Iranian Journal of Basic Medical Sciences (2012)
16. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
17. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
18. Decreased Phosphatidate Phosphohydrolase Activity in the Liver of Rats Exposed to Nicotinic Acid, Clofibrate and Gemfibrozil, Indian Journal of Pharmacology (1999)
19. Medicinal Plants and Bioactive Natural Compounds As Inhibitors of Hmg-Coa Reductase: A Literature Review, BioFactors (2020)
20. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
21. Comparison Common Equations for Ldl-C Calculation With Direct Assay and Developing a Novel Formula in Iranian Children and Adolescents: The Caspian V Study, Lipids in Health and Disease (2020)
22. Clinical Effects of Rhus Coriaria Fruits on Dyslipidemia308 in Adolescents: A Triple-Blinded Randomized Placebo-Controlled Trial, Medical archives (Sarajevo, Bosnia and Herzegovina) (2014)
23. The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals, African Journal of Pharmacy and Pharmacology (2011)
24. Inverse Association of Legume Consumption and Dyslipidemia: Isfahan Healthy Heart Program, Journal of Clinical Lipidology (2014)
25. Nutraceuticals in Hyperlipidemic Children: A Systematic Review and Meta-Analysis, International Journal of Pediatrics (2016)
26. Astaxanthin Improves Fatty Acid Dysregulation in Diabetes by Controlling the Ampk-Sirt1 Pathway, EXCLI Journal (2023)
27. The Effect of Fasting in Ramadan on the Values and Interrelations Between Biochemical, Coagulation and Hematological Factors, Annals of Saudi Medicine (2000)
28. Effect of Cardiac Rehabilitation on Lipid Profile, Journal of Association of Physicians of India (2003)
29. Increased Membrane Lipid Peroxidation and Decreased Na+/K+-Atpase Activity in Erythrocytes of Patients With Stable Coronary Artery Disease, Coronary Artery Disease (2015)
30. Rice Bran Oil Decreases Total and Ldl Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Hormone and Metabolic Research (2016)
31. Dietary Patterns in Relation to Lipid Profiles Among Iranian Adults, Journal of Cardiovascular and Thoracic Research (2019)
32. Study of Saturated Fatty Acids in Different Traditional Foods Distributed in Isfahan, Iran, Journal of Health System Research (2020)
33. The Effects of Aerobic Exercises on the Serum Oxidized Ldl and Total Antioxidant Capacity in Non-Active Men, CVD Prevention and Control (2008)
34. The Effect of Allium Hirtifolium Bulb on Serum Lipid Profile in Adult Patients With Hyperlipidemia: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Complementary Therapies in Clinical Practice (2022)
35. Is Friedewald Formula a Good Estimation for Low Density Lipoprotein Level in Iranian Population?, Journal of Research in Medical Sciences (2012)
36. Association Between the Index of Nutritional Quality and Lipid Profile in Adult Women, Endocrinology, Diabetes and Metabolism (2022)
37. The Effect of Walnut Consumption on Lipid Profiles of the First-Degree Relatives of Type Two Diabetes Mellitus Patients (T2dm) With Prediabetes, Pakistan Journal of Medical Sciences (2013)
38. Increased Leukocyte Abca1 Gene Expression in Post-Menopausal Women on Hormone Replacement Therapy, Gynecological Endocrinology (2011)
39. Effect of Glycyrrhiza Glabra Extract on Aorta Wall Atherosclerotic Lesion in Hypercholesterolemic Rabbits, Pakistan Journal of Nutrition (2007)
40. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
41. Interaction of Cholesterol Ester Transfer Protein Polymorphisms, Body Mass Index, and Birth Weight With the Risk of Dyslipidemia in Children and Adolescents: The Caspian‐Iii Study, Iranian Journal of Basic Medical Sciences (2015)
42. Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10-18 Years Old, Clinical Chemistry (2007)
43. Possible Involvement of Hepatic Phosphatidate Phosphohydrolase in the Mechanisms of Actions of Certain Antilipemic Drugs in Rats, Iranian Journal of Pharmaceutical Research (2007)
44. Effect of Hormone Replacement Therapy on Total Serum Anti-Oxidant Potential and Oxidized Ldl/ß2-Glycoprotein I Complexes in Postmenopausal Women, Endocrine Journal (2010)
45. Association Between Ultra-Processed Foods Intake With Lipid Profile: A Cross-Sectional Study, Scientific Reports (2023)
46. Evaluation Between Fat Distribution in Abdominal Ct Scan With Some Physical and Biochemical Variable in Ischemic Patients: Gaami Study, Journal of Isfahan Medical School (2011)
47. Effect of Gundelia Tournefortii L. on Some Cardiovascular Risk Factors in an Animal Model, Journal of HerbMed Pharmacology (2017)
48. Anethum Graveolens and Hyperlipidemia: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2014)
49. Association of Dietary Fats With Ischemic Heart Disease (Ihd): A Case–Control Study, Journal of Health, Population and Nutrition (2024)
50. Association Between Hdl Particles Size and Myeloperoxidase/ Paraoxonase-1 (Mpo/Pon1) Ratio in Patients With Acute Coronary Syndrome, Acta Medica Iranica (2013)