Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of a Lifestyle Modification Trial Among Phenotypically Obese Metabolically Normal and Phenotypically Obese Metabolically Abnormal Adolescents in Comparison With Phenotypically Normal Metabolically Obese Adolescents Publisher Pubmed



Kelishadi R1 ; Hashemipour M2 ; Sarrafzadegan N3 ; Mohammadifard N4 ; Alikhasy H4 ; Beizaei M1 ; Sajjadi F4 ; Poursafa P5 ; Amin Z6 ; Ghatrehsamani S1 ; Khavarian N1 ; Siadat ZD7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Preventive Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pediatric Endocrinology Department, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nutrition Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Isfahan University of Technology, Isfahan, Iran
  6. 6. Research and Training Unit, Isfahan Provincial Physical Activity and Sport Organization, Isfahan, Iran
  7. 7. Research Unit, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Maternal and Child Nutrition Published:2010


Abstract

This study aimed to assess the effects of a 2-month lifestyle modification trial on cardio-metabolic abnormalities and C-reactive protein (CRP) among obese adolescents with metabolic syndrome [phenotypically obese metabolically abnormal (POMA)] and obese adolescents without a cardio-metabolic disorder [phenotypically obese metabolically normal (POMN)], as well as in normal-weight adolescents with at least one cardio-metabolic disorder [phenotypically normal metabolically obese (PNMO)].The study comprised 360 adolescents assigned in three groups of equal number of POMN, POMA and PNMO. They were enrolled in a trial consisting of aerobic activity classes, diet and behaviour modification, and were recalled after 6 months.Overall, 94.7% of participants completed the 2-month trial, and 87.3% of them returned after 6 months. The mean CRP was not significantly different between the POMA and PNMO groups, but was higher than in the POMN group. After the trial, body mass index (BMI) and waist circumference (WC) decreased in obese participants, and the mean body fat mass decreased in all groups. At 2 months, the mean total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and CRP decreased in the POMA and PNMO groups. After 2 and 6 months, the decrease in mean TC, LDL-C, TG, CRP and systolic blood pressure was greater in the POMA than in the POMN group. The magnitude of decrease in CRP correlated with that of BMI, WC, fat mass, TG, TC and LDL-C.Lifestyle modification programmes for primordial/primary prevention of chronic diseases would be beneficial at the population level and should not be limited to obese children. © 2009 Blackwell Publishing Ltd.
Related Docs
View other Related Docs
1. Childhood Overweight, Obesity, and the Metabolic Syndrome in Developing Countries, Epidemiologic Reviews (2007)
2. Factors Associated With the Metabolic Syndrome in a National Sample of Youths: Caspian Study, Nutrition, Metabolism and Cardiovascular Diseases (2008)
3. Can a Trial of Motivational Lifestyle Counseling Be Effective for Controlling Childhood Obesity and the Associated Cardiometabolic Risk Factors?, Pediatrics and Neonatology (2012)
4. An Overview of a National Surveillance Program in Iran for Prevention of Chronic Non-Communicable Diseases From Childhood: Caspian Study, Iranian Journal of Public Health (2009)
5. Association of Breakfast Intake With Cardiometabolic Risk Factors, Jornal de Pediatria (2013)
6. Ethnic Disparities of the Metabolic Syndrome in Population-Based Samples of German and Iranian Adolescents, Metabolic Syndrome and Related Disorders (2010)
7. A Three-Country Study on the Components of the Metabolic Syndrome in Youths: The Big Study, International Journal of Pediatric Obesity (2010)
8. First Nationwide Study of the Prevalence of the Metabolic Syndrome and Optimal Cutoff Points of Waist Circumference in the Middle East: The National Survey of Risk Factors for Noncommunicable Diseases of Iran, Diabetes Care (2009)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (223)
Nizal Sarrafzadegan (47)
Other Related Docs
9. Hypertriglyceridemic Waist Phenotype and Associated Lifestyle Factors in a National Population of Youths: Caspian Study, Journal of Tropical Pediatrics (2008)
10. Familial Aggregation of the Components of Metabolic Syndrome, Pakistan Journal of Medical Sciences (2012)
11. Comparing the Validity of Continuous Metabolic Syndrome Risk Scores for Predicting Pediatric Metabolic Syndrome: The Caspian-V Study, Journal of Pediatric Endocrinology and Metabolism (2019)
12. An Overview on the Successes, Challenges and Future Perspective of a National School-Based Surveillance Program: The Caspian Study, Journal of Diabetes and Metabolic Disorders (2014)
13. Can a Dairy-Rich Diet Be Effective in Long-Term Weight Control of Young Children?, Journal of the American College of Nutrition (2009)
14. Short- and Long-Term Relationships of Serum Ghrelin With Changes in Body Composition and the Metabolic Syndrome in Prepubescent Obese Children Following Two Different Weight Loss Programmes, Clinical Endocrinology (2008)
15. Inflammation-Induced Atherosclerosis As a Target for Prevention of Cardiovascular Diseases From Early Life, Open Cardiovascular Medicine Journal (2010)
16. Metabolic Syndrome and Its Determinants in a Sample of Young Iranian Children With Obesity, Pakistan Journal of Medical Sciences (2013)
17. Tri-Ponderal Mass Index and Body Mass Index in Prediction of Pediatric Metabolic Syndrome: The Caspian-V Study, Archives of Endocrinology and Metabolism (2020)
18. Joint Association of Screen Time and Physical Activity With Cardiometabolic Risk Factors in a National Sample of Iranian Adolescents: The Caspianiii Study, PLoS ONE (2016)
19. Prevalence of Different Metabolic Phenotypes of Obesity in Iranian Children and Adolescents: The Caspian V Study, Journal of Diabetes and Metabolic Disorders (2018)
20. Factors Associated With Insulin Resistance and Non-Alcoholic Fatty Liver Disease Among Youths, Atherosclerosis (2009)
21. Metabolic Syndrome and Associated Factors in Iranian Children and Adolescents: The Caspian-V Study, Journal of Cardiovascular and Thoracic Research (2018)
22. The Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in a Population-Based Sample of Overweight/Obese Children in the Middle East, Pediatric Diabetes (2010)
23. Metabolic Syndrome and Cardiovascular Risk Factors in a National Sample of Adolescent Population in the Middle East and North Africa: The Caspian Iii Study, International Journal of Endocrinology (2013)
24. Outcomes of a Comprehensive Healthy Lifestyle Program on Cardiometabolic Risk Factors in a Developing Country: The Isfahan Healthy Heart Program, Archives of Iranian Medicine (2013)
25. Lifestyle and Environmental Factors Associated With Inflammation, Oxidative Stress and Insulin Resistance in Children, Atherosclerosis (2009)
26. Effects of Adenoidectomy on Markers of Endothelial Function and Inflammation in Normal-Weight and Overweight Prepubescent Children With Sleep Apnea, Journal of Research in Medical Sciences (2011)
27. Association Between Neck and Wrist Circumferences and Cardiometabolic Risk in Children and Adolescents: The Caspian-V Study, Nutrition (2017)
28. Association of Physical Activity and the Metabolic Syndrome in Children and Adolescents: Caspian Study, Hormone Research (2007)
29. Factor Analysis of Cardiovascular Risk Clustering in Pediatric Metabolic Syndrome: Caspian Study, Annals of Nutrition and Metabolism (2007)
30. First Report on the Validity of a Continuous Metabolic Syndrome Score As an Indicator for Metabolic Syndrome in a National Sample of Paediatric Population - the Caspian-Iii Study, Endokrynologia Polska (2013)
31. Genetic Association With Low Concentrations of High Density Lipoprotein-Cholesterol in a Pediatric Population of the Middle East and North Africa: The Caspian-Iii Study, Atherosclerosis (2014)
32. Obesity and Metabolic Syndrome Among a Representative Sample of Iranian Adolescents, Southeast Asian Journal of Tropical Medicine and Public Health (2012)
33. Validity of Triglyceride–Glucose Index As an Indicator for Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
34. Association of Anthropometric Measures With Cardiovascular Risk Factors and Metabolic Syndrome in Normal-Weight Children and Adolescents: The Caspian Iii Study, Obesity Facts (2013)
35. Association of Alanine Aminotransferase Concentration With Cardiometabolic Risk Factors in Children and Adolescents: The Caspian-V Cross-Sectional Study, Sao Paulo Medical Journal (2018)
36. Does the Impact of Metabolic Syndrome on Cardiovascular Events Vary by Using Different Definitions? Chronic Disease Epidemiology, BMC Public Health (2015)
37. Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents the Caspian-Iii Study, Iranian Journal of Kidney Diseases (2016)
38. A Randomized, Triple Masked, Placebo-Controlled Clinical Trial for Controlling Childhood Obesity, World Journal of Pediatrics (2010)
39. Association of a Body Shape Index and Hip Index With Cardiometabolic Risk Factors in Children and Adolescents: The Caspian-V Study, Journal of Diabetes and Metabolic Disorders (2021)
40. Association of Alanine Aminotransferase With Different Metabolic Phenotypes of Obesity in Children and Adolescents: The Caspian-V Study, Frontiers in Endocrinology (2020)
41. Metabolic Syndrome: An Emerging Public Health Problem in Iranian Women: Isfahan Healthy Heart Program, International Journal of Cardiology (2008)
42. The Effect of Mediterranean Diet on Inflammatory Biomarkers and Components of Metabolic Syndrome in Adolescent Girls, Journal of Endocrinological Investigation (2023)
43. Is Family History of Premature Cardiovascular Diseases Appropriate for Detection of Dyslipidemic Children in Population-Based Preventive Medicine Programs? Caspian Study, Pediatric Cardiology (2006)
44. Moderate Replacement of Carbohydrates by Dietary Fats Affects Features of Metabolic Syndrome: A Randomized Crossover Clinical Trial, Nutrition (2014)
45. Assessing Body Shape Index As a Risk Predictor for Cardiovascular Diseases and Metabolic Syndrome Among Iranian Adults, Nutrition (2014)
46. Reference Curves of Anthropometric Indices and Serum Lipid Profiles in Representative Samples of Asian and European Children, Archives of Medical Science (2008)
47. Association of Parental Obesity With Cardiometabolic Risk Factors in Their Children: The Caspian-V Study, PLoS ONE (2018)
48. Are Active and Passive Smoking Associated With Cardiometabolic Risk Factors in Adolescents? the Caspian-Iii Study, Paediatrics and International Child Health (2016)
49. Association of Anthropometric Indices With Continuous Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
50. Association of Cell Blood Counts and Cardiometabolic Risk Factors Among Young Obese Children, Saudi Medical Journal (2011)