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Factors Associated With Insulin Resistance and Non-Alcoholic Fatty Liver Disease Among Youths Publisher Pubmed



Kelishadi R1 ; Cook SR2 ; Amra B3 ; Adibi A3
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Authors Affiliations
  1. 1. Pediatric Preventive Cardiology Department, Isfahan Cardiovascular Research Centre, Isfahan University of Medical Sciences, Isfahan, P.O. Box 81465-1148, Iran
  2. 2. Department of Pediatrics, University of Rochester Medical Center, NY, United States
  3. 3. Isfahan School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Atherosclerosis Published:2009


Abstract

Objectives: To compare the cardio-metabolic risk factors, fitness and lifestyle among adolescents with and without weight disorders and/or metabolic abnormality, and to identify the factors associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) in this age group. Methods: This cross-sectional study comprised 100 adolescents (12-18 years) consisting of four subgroups of normal weight/obese with and without components of the metabolic syndrome. Fasting blood glucose, insulin, lipid profile, apolipoproteins A, B, CRP, oxidized-LDL, malondialdehyde and alanine aminotransferase (ALT) were examined. Cardiorespiratory fitness (CRF) and the sonographic findings of liver and carotid intima media thickness were determined. Results: Overall 95 participants completed all tests. Serum lipids, lipoproteins, the markers of inflammation and oxidative stress as well as the C-IMT of normal weight children with a metabolic abnormality were similar to obese children. CRF had the highest inverse correlation with HOMA-IR and ALT. Physical activity and healthy eating index had similar inverse correlation with HOMA-IR and ALT. ApoB/ApoA-I had significant independent association with upper quartiles of HOMA-IR and ALT. Waist circumference and ApoB/ApoA-I ratio had the highest odds ratio in increasing the risk of insulin resistance and NAFLD, whereas CRF followed by healthy eating index decreased this risk significantly. C-IMT was significantly associated with insulin resistance and NAFLD. Conclusions: We found significant associations between insulin resistance and NAFLD, and similar risk factors and protective factors for these two inter-related disorders; in this regard the role of CRF and apolipoprotein B to apolipoprotein A-I (ApoB/ApoA-I) ratio in the pediatric age group is underscored. © 2008 Elsevier Ireland Ltd. All rights reserved.
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