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Effect of Nigella Sativa Oil Extract on Cardiometabolic Risk Factors in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Hadi S1 ; Daryabeygikhotbehsara R2 ; Mirmiran P3 ; Mcvicar J2 ; Hadi V4 ; Soleimani D5 ; Askari G1, 6
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Institute for Physical Activity and Nutrition (IPAN), Deakin University, Melbourne, Burwood, Australia
  3. 3. Department of Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Health, Science and Research Branch, AJA University of Medical Sciences, Tehran, Iran
  5. 5. Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Phytotherapy Research Published:2021


Abstract

The objective of this study was to determine the effects of Nigella sativa oil extract on cardiometabolic risk factors in people with type 2 diabetes (T2D). A randomized, controlled, clinical trial was conducted on 43 patients with T2D (23 women and 20 men; aged 53.5 ± 7.4 years). The intervention group (N = 23) received two 500-mg per day soft gel capsules containing Nigella sativa oil extract and the control group (N = 20) received two identical placebo soft gel capsules containing sunflower oil per day for the same period, 8 weeks. Pre- and post-intervention cardiometabolic risk factors were measured. Compared with the placebo, the N. sativa oil significantly decreased FBS (p =.03(, HbA1c (p =.001), total cholesterol (p =.04), TG (p =.003), LDL-c (p =.001), BMI (p <.001), waist circumference (p <.001), SBP (p =.001), and DBP (p =.002). HOMA-IR (p =.51) and HDL-c (p =.91) did not change significantly following Nigella sativa supplementation. Nigella sativa oil exerted beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with T2D. Further long-term trials in the future may help confirm the current therapeutic benefits of Nigella sativa in T2D. © 2021 John Wiley & Sons, Ltd.
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