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Effects of Nigella Sativa Supplementation on Lipid Profiles in Adults: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Rounagh M1 ; Musazadeh V2 ; Hosseininejadmohebati A3 ; Falahatzadeh M4 ; Kavyani Z7 ; Rostami RB5 ; Vajdi M6
Authors
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Authors Affiliations
  1. 1. Islamic Azad University Science and Research Branch of Medical Science, Tehran, Iran
  2. 2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
  4. 4. Department of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Clinical Nutrition, Faculty of Nutrition Sciences and Food Industries, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical Nutrition ESPEN Published:2024


Abstract

Background and aim: Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants. Methods: We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval. Results: The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: −1.78; 95% CI: −2.20, −1.37, p < 0.001), triglycerides (TG) (SMD: −1.2725; 95% CI: −1.67, −0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: −2.45; 95% CI: −3.06, −1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001). Conclusion: N. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent. © 2024 European Society for Clinical Nutrition and Metabolism
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