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Whole Exome Sequencing and Whole Genome Sequencing for Investigation of the Genetic Basis of Obesity: A Rapid Review



Dehghan R1 ; Salehi M2
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Genetics and Molecular Biology, School of Medicine, Pediatric Inherited Diseases Research Center, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Bahrain Medical Bulletin Published:2023

Abstract

Objective: In recent decades, the prevalence of obesity has reached a global epidemic level. This study was done to assess the whole exome sequencing and whole genome sequencing methods used to investigate the genetic basis of obesity. Materials and Methods: Different studies on Pubmed, Scopuis, Google Scholar and other data bases were extracted and their findings were analyzed. Results: Childhood obesity has risen to alarming levels as World Health Organization (WHO) estimates that there were 38.2 million children under the age of 5 years with overweight or obesity in 2019. It has been shown that genetic factors also play a key role in the risk of obesity, and strong evidence suggests that BMI is highly heritable. However, in both adults and children, a major part of the genetic aetiology of obesity is still unknown. Recent advances and increasing affordability of whole exome sequencing (WES) and/or whole genome sequencing (WGS) have provided a rapid and comprehensive method for identifying the novel genes in obesity, particularly in children with severe early-onset obesity. Conclusion: This rapid review aimed to review a variety of literature reporting novel candidate genes for non-syndromic obesity identified through applying WES and WGS techniques in humans. © 2023, Bahrain Medical Bulletin. All rights reserved.
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