Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Screening of Congenital Hypothyroidism in Preterm, Low Birth Weight and Very Low Birth Weight Neonates: A Systematic Review Publisher Pubmed



Hashemipour M1, 2 ; Hovsepian S3 ; Ansari A4 ; Keikha M5 ; Khalighinejad P4 ; Niknam N4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Emam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Epidemiology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Pediatrics and Neonatology Published:2018


Abstract

Evidence from different screening programs indicated that the rate of congenital hypothyroidism (CH) was higher in pre-term and low-birth-weight (LBW) newborns than normal ones. Incomplete development of hypothalamic–pituitary axis in this group of neonates results in the delayed rise of TSH and missing cases with CH. Hence, there is a great need for a practicable systematic screening method for proper diagnosis of CH in this group of neonates. In this review, we systematically reviewed papers with the following key words ([Congenital Hypothyroidism AND Screening AND Thyroxine AND Thyroid Stimulating Hormone AND Low Birth Weight AND Premature]) in international electronic databases including PubMed, Scopus, and Google Scholar. After quality assessment of selected documents, data of finally included papers were extracted. In this review, 1452 papers (PubMed: 617; Scopus: 714; Google scholar: 121) were identified through electronic database search. One hundred and ninety four articles were assessed for eligibility, from which 36 qualified articles were selected for final evaluation. From the reviewed articles, 38.9%, 11.11% and 8.3% recommended rescreening in this group of neonates, lowering the screening cutoff of TSH and using cutoffs according to the gestational age, respectively. Some of them (13.9%) recommended using both TSH and T4 for screening of preterm infants. After reviewing available data, we recommend repeating the screening test in pre-term, LBW and very-low- birth-weight (VLBW) infants at age of two, six and ten weeks by measuring TSH and FT4 levels simultaneously and considering TSH = 10 mU/L as the cutoff level for positive and suspicious cases. © 2017
Other Related Docs
10. Prevalence of Transient Congenital Hypothyroidism in Central Part of Iran, Journal of Research in Medical Sciences (2013)
16. Congenital Hypothyroidism; Is There Any Familial Component?, Journal of Isfahan Medical School (2009)
25. The Role of Ultrasonography in Primary Congenital Hypothyroidism, Journal of Research in Medical Sciences (2011)
29. Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism, JCRPE Journal of Clinical Research in Pediatric Endocrinology (2012)
34. Age of Menarche and Final Height in Patients With Permanent Congenital Hypothyroidism, Annals of Pediatric Endocrinology and Metabolism (2024)
42. Spatial Distribution of Congenital Hypothyroidism, Archives of Iranian Medicine (2021)