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An Artificial Soft Tissue Made of Nano-Alginate Polymer Using Bioxfab 3D Bioprinter for Treatment of Injuries Publisher



Salimi K1 ; Eghbali S2 ; Jasemi A3 ; Shokrani Foroushani R4 ; Joneidi Yekta H5 ; Latifi M6 ; Sabersamandari S5 ; Khandan A5
Authors
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Authors Affiliations
  1. 1. Genetics Department, Falavarjan Branch, Islamic Azad University, Esfahan, Iran
  2. 2. Nourdanesh Institute of Higher Education, Esfahan, Iran
  3. 3. Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. New Technology Research Centre, Advanced Materials Research Center, Amirkabir University of Technology, Tehran, Iran
  6. 6. Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran

Source: Nanochemistry Research Published:2020


Abstract

Some pulsed tissues are replaced with non-pulsed damaged tissues that may endanger the heart function after a heart attack. The restoration is performed by a patch tissue to repair defective tissues. It is supposed to attach to the outside of the heart and connect to the wounded area. The patch is made of a conductive polymer on which a separate electrical polymer called “alginate” through a process called 3D bioprinter was fabricated. The mechanism of the prepared patch for biological and cell behavior needs to be investigated. Besides, we explain the results of the combination of these polymers with natural and synthetic polymer composites. As a natural and biological soft patch for cardiovascular disease (CVD), the adhesion of cells to patch is more efficient and important. In this study, we used a novel technique to print sodium alginate for CVD problems with a soft hydrogel patch loaded by a restorative drug. The mechanical and biological properties and severity of degradability of the patch can be controlled using a specific polymer. In other words, by producing soft tissue patches, researchers and clinical surgeons can obtain more desirable properties made of natural and synthetic polymer composites for the treatment of heart disease. In this study, four CVD patches are fabricated using 3D bioprinter X4bioFab with various amounts of drug on their surfaces containing 2%, 4%, 6%, and 8%. The obtained values for mechanical and biological performance present proper features for the sample containing 6% drug. The results indicated that the prepared patch can be a suitable candidate for heart disease with sufficient cell attachment after a while. © 2020, Iranian Chemical Society. All rights reserved.
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