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Nanofibrous Scaffolds With Biomimetic Composition for Skin Regeneration Publisher Pubmed



Khalili S1, 2 ; Khorasani SN1 ; Razavi SM3 ; Hashemibeni B4 ; Tamayol A2
Authors
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Authors Affiliations
  1. 1. Department of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, 02139, MA, United States
  3. 3. Department of Oral and Maxillofacial Pathology, School of Dentistry and Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Applied Biochemistry and Biotechnology Published:2019


Abstract

Treatments of skin injuries caused by trauma and diseases are among the most considerable medical problems. The use of scaffolds that can cover the wound area and support cellular ingrowth has shown great promise. However, mimicking the physicochemical properties of the native skin extracellular matrix (ECM) is essential for the successful integration of these scaffolds. Elastin has been known as the second main protein-based component of the native skin ECM. In this research, scaffolds containing gelatin, cellulose acetate, and elastin were fabricated using electrospinning. Subsequently, the effects of soluble elastin on the physical, mechanical, and biological properties of the prepared scaffolds were studied. The results confirmed that the presence of elastin in the composition changed the fiber morphology from straight to ribbon-like structure and decreased the swelling ratio and degradation rate of the scaffold. In vitro experiments showed that elastin-containing scaffolds supported the attachment and proliferation of fibroblast cells. Overall, the obtained results suggest the ternary blend of gelatin, cellulose acetate, and elastin as a good candidate for skin tissue engineering. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
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