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Nanofibrous Scaffolds With Biomimetic Structure Publisher Pubmed



Khalili S1, 2, 3 ; Nouri Khorasani S1 ; Razavi M4, 5 ; Hashemi Beni B6 ; Heydari F5 ; Tamayol A2, 3
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Authors Affiliations
  1. 1. Department of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02139, MA, United States
  3. 3. Harvard- MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, MA, United States
  4. 4. Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  5. 5. Torabinejad Dental Sciences Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  6. 6. Department of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Journal of Biomedical Materials Research - Part A Published:2018


Abstract

This research studies the effect of using a grid-like pattern as a collector on increasing the pore size of the electrospun gelatin/cellulose acetate/elastin scaffolds. The morphological study showed an enlargement in pore size and a decline in fiber diameter in comparison with the scaffold fabricated using conventional flat sheet collectors. The use of the pattern increased the swelling ratio and degradation rate of the scaffold. Investigating the tensile properties of scaffolds revealed that the patterned collector increased the elongation at break up to 145%. In vitro experiments revealed the patterned scaffold as a good substrate for attachment and proliferation of fibroblast cells. Overall, our results indicated that the patterned scaffold of gelatin/cellulose acetate/elastin could provide a better microenvironment for fibroblast cells compared to the conventional scaffolds. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 370–376, 2018. © 2017 Wiley Periodicals, Inc.
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