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The Relationship Between Serum Ghrelin Levels and Bone Metabolism Markers and Severity Anemia in Non-Diabetic Hemodialysis Patients; a Pilot Study Publisher



Mahmoodnia L1 ; Beigrezaei S2 ; Tamadon MR3 ; Jafari T4 ; Kafeshani M5 ; Mahmoodi F1 ; Dehkordi AH6 ; Amiri M7
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  2. 2. School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Department of Biochemistry and Nutrition, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Food Security Research Center, Department of Clinical Nutrition/Community Nutrition/Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Social determinants of Health Research Center/Department of Medical-Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Journal of Nephropathology Published:2018


Abstract

Background: Chronic kidney disease (CKD) is a consequence of progressive and irreversible destruction of nephrons, mainly due to uncontrolled diabetes mellitus and high blood pressure. Ghrelin is a peptide hormone which could play a substantial role in hunger sensation, may increase body fat percentage and might adjust the long-term body weight and is mostly secreted in the stomach. Objectives: This study aimed to evaluate the relationship between ghrelin levels and various biochemical and demographic indices in a group of non-diabetic hemodialysis patients. Patients and Methods: Around 39 non-diabetic patients undergoing hemodialysis in Hajar hospital at Shahrekord city were enrolled. Results: The mean age of patients was 57.10 ± 20.20 years. Their mean weight was 56.65 ±16.25 kg. Their hemoglobin level mean was 10.43 ± 1.84 g/dL. The serum ghrelin level had a positive but not significant correlation with the age, dialysis quality, dosage, calcium level, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in these patients. Conclusions: More studies in this subject of hemodialysis patients to define the exact role of ghrelin in hemodialysis patients are recommended. © 2018 The Author(s).
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