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The Effect of Vitamin D Administration on Serum Leptin and Adiponectin Levels in End-Stage Renal Disease Patients on Hemodialysis With Vitamin D Deficiency: A Placebo-Controlled Double-Blind Clinical Trial Publisher



Naini AE1 ; Vahdat S1 ; Hedaiati ZP1 ; Shahzeidi S2 ; Pezeshki AH3 ; Nasri H1
Authors
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Authors Affiliations
  1. 1. Department of Nephrology, Division of Nephropathology, Nour Medical, Educational and Therapeutic Center, Isfahan, Iran
  2. 2. Department of Internal Medicine, Isfahan, Iran
  3. 3. Student of Medicine, Isfahan Medical Students Research Center (ISRC), Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2016


Abstract

Background: The prevalence of vitamin D deficiency is higher in end-stage renal disease (ESRD) patients compared to healthy populations. This deficiency could lead to several complications with different mechanisms and might result in reduced survival in patients. Leptin and adiponectin are messenger proteins with endocrine secretion from adipocytes and various effects in cellular mechanisms. The goal of this study was to find the effect of vitamin D administration on serum levels of leptin and adiponectin in ESRD patients. Materials and Methods: This double-blind randomized placebo-controlled clinical trial was carried out on 64 ESRD patients on hemodialysis in the Amin and Noor hospitals of Isfahan, Iran. Patients were categorized into two groups, on control and intervention; serum levels of vitamin D, leptin, and adiponectin were measured in both groups before and after the study. The intervention group was treated with vitamin D pearls, while the control group received placebo in the same manner. Results: The mean [standard deviation (SD)] ages of the patients were 62 (21) years and 60 (19) years in the control and treated groups, respectively. Conclusion: The change in serum level of vitamin D was statistically significant in the treatment group but not in the control group. The serum level of leptin was reduced in the treatment group, while the serum level of adiponectin increased significantly, but none of these changes were statistically significant in the control group. This study showed that vitamin D administration is associated with an increase in adiponectin and a decrease in leptin level in ESRD patients. © 2016 Journal of Research in Medical Sciences.
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