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Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats



Haghighi B1 ; Farsadi M1
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Authors Affiliations
  1. 1. Dept. of Clinical Biochemistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Biomedical Journal Published:2001

Abstract

Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in glycerolipid metabolism.
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