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Fabrication of Gehlenite Nanopowder Containing Electrospun Nanofibers for Bone Tissue Engineering Publisher



Doostmohammadi M1 ; Mehrasa M2 ; Bigham A5 ; Rafienia M6 ; Amini S1 ; Komeilynia Z3 ; Heidarian P4 ; Nasrinasrabadi B3
Authors
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Authors Affiliations
  1. 1. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, 761, Iran
  2. 2. Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, 83, Iran
  3. 3. Institute for Frontier Materials, Deakin University, Geelong, 3217, VIC, Australia
  4. 4. School of Engineering, Deakin University, Geelong, 3217, VIC, Australia
  5. 5. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 81745-33871, Iran
  6. 6. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, 81745-33871, Iran

Source: Fibers and Polymers Published:2021


Abstract

Bioactive Polycaprolactone/Collagen nanofibers containing gehlenite Nano-powder were fabricated using electrospinning for bone tissue engineering. The physicochemical properties of scaffolds measured using scanning electron microscopy, tensile test, FTIR spectroscopy, and water contact angle measurement test. A slight enhancement (∼20 nm) in fibers diameter was observed by adding gehlenite nanoparticles to the scaffolds, but the fiber diameter distributions for both scaffolds were within the normal range of extracellular matrix (50–500 nm). In vitro experiments demonstrated well attachment and higher proliferation of MG-63 cells on gehlenite nanoparticles containing scaffolds. Besides, the stimulatory cell differentiation effects of Polycaprolactone/Collagen/gehlenite scaffolds were demonstrated by Alizarin red staining. This study represents for advanced of the natural and synthetic polymers for bone tissue engineering. © 2021, The Korean Fiber Society for Fibers and Polymers and Springer.
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