Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Ternary Nanocomposite Fibrous Scaffold Composed of Poly(Ε-Caprolactone)/Gelatin/Gehlenite (Ca2al2sio7): Physical, Chemical, and Biological Properties in Vitro Publisher



Baghbadorani MA1 ; Bigham A2 ; Rafienia M3 ; Salehi H4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Advanced Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine (ATiM), Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Polymers for Advanced Technologies Published:2021


Abstract

Scaffolds are regarded as 3D substrates providing an appropriate environment through which the cells attachment, proliferation, and differentiation rate can be accelerated; based on their application, these scaffolds must have certain characteristics like suitable mechanical properties and porosity, desired degradation rate, and cell compatibility. In the present study, a novel nanocomposite fibrous scaffold composed of poly(ε-caprolactone) (PCL)/Gelatin (GT)/Gehlenite (GLN) nanoparticles was fabricated through electrospinning method. Different weight ratios of GLN nanoparticles in the fibrous scaffolds were added and optimized and a series of samples including PCL, PCL/GT, and PCL/GT/GLN scaffolds were constructed in order to reach a better comparison between the scaffolds. It turned out that 7% was the optimized GLN weight ratio to be included into the scaffolds without destroying the fibers structure. Different characterization techniques were applied to assess the physical and chemical properties of scaffolds. Moreover, the scaffolds' degradation rate, bioactivity potential, cell viability, attachment, DAPI and Alizarin staining, and ALP activity were assessed in vitro as well. The overall results indicate that the ternary scaffold (PCL/GT/GLN7%) has a promising potential for bone tissue regeneration. © 2020 John Wiley & Sons Ltd
Related Docs
View other Related Docs
1. A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold With Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies, Journal of the European Ceramic Society (2021)
2. Zn-Substituted Mg2sio4 Nanoparticles-Incorporated Pcl-Silk Fibroin Composite Scaffold: A Multifunctional Platform Towards Bone Tissue Regeneration, Materials Science and Engineering C (2021)
3. In Vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles, Journal of Medical Signals and Sensors (2021)
4. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
5. 3D Printed Polycaprolactone/Gelatin/Ordered Mesoporous Calcium Magnesium Silicate Nanocomposite Scaffold for Bone Tissue Regeneration, Journal of Materials Science: Materials in Medicine (2024)
6. Hierarchical Porous Mg2sio4-Cofe2o4 Nanomagnetic Scaffold for Bone Cancer Therapy and Regeneration: Surface Modification and in Vitro Studies, Materials Science and Engineering C (2020)
7. The Journey of Multifunctional Bone Scaffolds Fabricated From Traditional Toward Modern Techniques, Bio-Design and Manufacturing (2020)
8. Poly Glycerol Sebacate/ Polycaprolactone/ Carbon Quantum Dots Fibrous Scaffold As a Multifunctional Platform for Cardiac Tissue Engineering, Materials Chemistry and Physics (2021)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (99)
Mohammad Rafienia (74)
Other Related Docs
9. Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies, Polymers for Advanced Technologies (2020)
10. On the Bioactivity and Mechanical Properties of Gehlenite Nanobioceramic: A Comparative Study, Journal of Medical Signals and Sensors (2020)
11. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
12. A 3D Macroporous and Magnetic Mg2sio4-Cufe2o4 Scaffold for Bone Tissue Regeneration: Surface Modification, in Vitro and in Vivo Studies, Biomaterials Advances (2022)
13. Incorporation of Multi-Walled Carbon Nanotubes Into Electrospun Pcl/Gelatin Scaffold: The Influence on the Physical, Chemical and Thermal Properties and Cell Response for Tissue Engineering, Materials Technology (2020)
14. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
15. Tunable Cellular Interactions and Physical Properties of Nanofibrous Pcl-Forsterite: Gelatin Scaffold Through Sequential Electrospinning, Composites Science and Technology (2013)
16. A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold, Scientific Reports (2020)
17. Porous Titanium Scaffold Coated Using Forsterite/Poly-3-Hydroxybutyrate Composite for Bone Tissue Engineering, Surface and Coatings Technology (2019)
18. A Route Toward Fabrication of 3D Printed Bone Scaffolds Based on Poly(Vinyl Alcohol)–Chitosan/Bioactive Glass by Sol–Gel Chemistry, International Journal of Biological Macromolecules (2024)
19. Development of Novel Aligned Nanofibrous Composite Membranes for Guided Bone Regeneration, Journal of the Mechanical Behavior of Biomedical Materials (2013)
20. Electrospun Polycaprolactone/Gelatin/Bioactive Glass Nanoscaffold for Bone Tissue Engineering, International Journal of Polymeric Materials and Polymeric Biomaterials (2019)
21. Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
22. Ultra-Thin Electrospun Nanocomposite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Magnetic Mesoporous Bioactive Glasses for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2024)
23. Synthetic-Based Blended Electrospun Scaffolds in Tissue Engineering Applications, Journal of Materials Science (2022)
24. Formulation of Electrospun Mg-Fa/Poly (Ε-Caprolactone) Nanocomposite to Adjust Bioactivity, Biodegradability, and Cellular Interactions, Polymers for Advanced Technologies (2021)
25. Pcl/Agarose 3D-Printed Scaffold for Tissue Engineering Applications: Fabrication, Characterization, and Cellular Activities, Research in Pharmaceutical Sciences (2023)
26. Multifunctional Electrospun Polyvinyl Alcohol/Gellan Gum/Polycaprolactone Nanofibrous Membrane Containing Pentoxifylline to Accelerate Wound Healing, Polymer Bulletin (2023)
27. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)
28. Investigation of Physical, Mechanical and Biological Properties of Polyhydroxybutyrate-Chitosan/Graphene Oxide Nanocomposite Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
29. Evaluating the Osteogenic Properties of Polyhydroxybutyrate-Zein/Multiwalled Carbon Nanotubes (Mwcnts) Electrospun Composite Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2024)
30. Osteogenic Potential of Phb-Lignin/Cellulose Nanofiber Electrospun Scaffold As a Novel Bone Regeneration Construct, International Journal of Biological Macromolecules (2023)
31. Fabrication and Characterization of Polycaprolactone Fumarate/Gelatin-Based Nanocomposite Incorporated With Silicon and Magnesium Co-Doped Fluorapatite Nanoparticles Using Electrospinning Method, Materials Science and Engineering C (2020)
32. Polycaprolactone-Chitosan/Multi-Walled Carbon Nanotube: A Highly Strengthened Electrospun Nanocomposite Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
33. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
34. Assessing Physicochemical, Mechanical, and in Vitro Biological Properties of Polycaprolactone/Poly(Glycerol Sebacate)/Hydroxyapatite Composite Scaffold for Nerve Tissue Engineering, Materials Chemistry and Physics (2022)
35. Optimization and Characterization of Polyhydroxybutyrate/Lignin Electro-Spun Scaffolds for Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
36. Platelet Rich Fibrin Containing Nanofibrous Dressing for Wound Healing Application: Fabrication, Characterization and Biological Evaluations, Materials Science and Engineering C (2021)
37. Evaluation of the Effects of Zein Incorporation on Physical, Mechanical, and Biological Properties of Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
38. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
39. Implementing Taguchi Method to Analyze Electrospinning Parameters Influence on Mg-Doped Fluorapatite Nanoparticles-Poly (Ε-Caprolactone) Nanocomposite Scaffold (Mg-Fa Nps/Pcl) Properties, Polymers for Advanced Technologies (2020)
40. Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells, Journal of Biomaterials Science, Polymer Edition (2022)
41. Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs, Polymers (2022)
42. Preparation of Fibrin/Poly Vinyl Alcohol Electrospun Nanofibers Scaffold for Tissue Engineering Applications, Journal of Isfahan Medical School (2016)
43. Fabrication and Characterization of Chitosan-Gelatin/Single-Walled Carbon Nanotubes Electrospun Composite Scaffolds for Cartilage Tissue Engineering Applications, Polymers for Advanced Technologies (2022)
44. Nano/Micro Hybrid Scaffold of Pcl or P3hb Nanofibers Combined With Silk Fibroin for Tendon and Ligament Tissue Engineering, Journal of Applied Biomaterials and Functional Materials (2015)
45. Highly Porous 3D Printed Scaffold Incorporated With Graphene Oxide-Merwinite and Coated With Igf1 Loaded Nanofibers for Calvarial Defect Repair, Journal of Polymers and the Environment (2024)
46. Baghdadite/Polycaprolactone Nanocomposite Scaffolds: Preparation, Characterisation, and in Vitro Biological Responses of Human Osteoblast-Like Cells (Saos-2 Cell Line), Materials Technology (2020)
47. Nanofibrous Chitosan-Polyethylene Oxide Engineered Scaffolds: A Comparative Study Between Simulated Structural Characteristics and Cells Viability, BioMed Research International (2014)
48. Degradable and Biocompatible Nanofibrous Scaffold Incorporating a Natural Cell Culture Medium for Skin Tissue Engineering, Physica Scripta (2024)
49. Characterization of Silk/Poly 3-Hydroxybutyrate-Chitosan-Multi-Walled Carbon Nanotube Micro-Nano Scaffold: A New Hybrid Scaffold for Tissue Engineering Applications, Journal of Medical Signals and Sensors (2018)
50. Synergetic Effect of Bioglass and Nano Montmorillonite on 3D Printed Nanocomposite of Polycaprolactone/Gelatin in the Fabrication of Bone Scaffolds, International Journal of Biological Macromolecules (2024)