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Lowering Effect of Valsartan on Fetuin-A in Type 1 Diabetes Mellitus Pubmed



Gheissari A1 ; Javanmard SH2 ; Shirzadi R3 ; Amini M4 ; Khalili N4
Authors
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Authors Affiliations
  1. 1. Isfahan Kidney Diseases Research Center, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Kidney Diseases Published:2013


Abstract

Introduction. Fetuin-A (A2-HS-glycoprotein) is a protein that plays several functions in human physiology and pathophysiology. The role of fetuin-A in type 1 diabetes mellitus (DM) has been less studied. We investigated the serum levels of fetuin-A in type 1 diabetic patients with microalbuminuria. Furthermore, the blocking effect of renin-angiotensin-aldosteron system on serum levels of fetuin-A was assessed. Materials and Methods. From January 2010 to May 2011, 32 patients with type 1 DM with confirmed microalbuminuria were included in this study in Isfahan, Iran. Serum fetuin-A levels before and 8 weeks after valsartan administration were measured. In addition, serum lipid profile, creatinine, hemoglobin A1c, and urine microalbuminuria were determined. Results. The mean age of participants was 21.65 ± 0.38 years. Before valsartan administration, the mean values of fetuin-A were not significantly different between males and females (64.22 ± 1.77 ng/mL versus 61.39 ± 3.35 ng/mL, respectively). After valsartan administration, serum levels of fetuin-A and urine albumin-creatinine significantly decreased. A negative correlation was observed between serum fetuin-A level after valsartan administration and serum low-density lipoprotein cholesterol level (P =.007, r = -0.507). Conclusions. Administration angiotensin receptor blockers concomitantly decreases fetuin-A levels and urine albumin levels.
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