Isfahan Covid Cohort Study: Rationale, Methodology, and Initial Results Publisher



Sarrafzadegan N^{1, 2} ; Mohammadifard N¹ ; Javanmard SH³ ; Haghighatdoost F⁴ ; Nouri F⁵ ; Ahmadian M⁶ ; Nasirian M⁷ ; Sayyah M⁸ ; Najafian J⁴ ; Shafiei M¹ ; Alikhasi H⁹ ; Javanbakht S¹⁰ ; Nilforoushzadeh F¹ ; Bagheri F¹ Show All Authors Show Affiliations
Source: Journal of Research in Medical Sciences Published:2022

Abstract

Background: The Isfahan COVID Cohort (ICC) study was designed to investigate the short- and long-term consequences of patients with COVID-19 in Iran. This report presents the rationale, methodology, and initial results of ICC. Materials and Methods: ICC is a 5-year multicentric prospective cohort study that is ongoing on two groups including 5000 patients hospitalized with moderate or severe and 800 nonhospitalized patients with mild or asymptomatic COVID-19 in Isfahan. The ICC endpoints are morbidity, mortality, incident cases, or worsening of underlying noncommunicable diseases (NCDs) and their risk factors. In the current analysis, we examined the persistent symptoms and incident NCDs or risk factors in 819 previously hospitalized patients who completed 1-year follow-up. Results: The two most common symptoms were joint pain/myalgia (19.7%) and dry cough/dyspnea (18.7%). Around 60% of patients had at least one symptom which was more common among women than men and in middle aged than younger or older patients. Female (odds ratio [OR] =1.88, 95% confidence interval [CI]: 1.39-2.55) and highly-educated patients (OR = 2.18, 95% CI: 1.56-3.04) had higher risk of having any symptom in 1-year follow-up. New cases of hypertension followed by diabetes then coronary heart disease (CHD) were the most common incident NCDs. Conclusion: During 1-year follow-up after hospital discharge, about 60% of patients experienced persistent symptoms. Incident hypertension, diabetes, and CHD were the most common events seen. Close monitoring and extensive health services with integrative approaches are needed to improve the health status of these patients. © 2022 Journal of Research in Medical Sciences | Published by Wolters Kluwer - Medknow.