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Pathogenic and Therapeutic Roles of Cytokines in Acute Myeloid Leukemia Publisher Pubmed



Karimdadi Sariani O1 ; Eghbalpour S2 ; Kazemi E3 ; Rafiei Buzhani K4 ; Zaker F5
Authors
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Authors Affiliations
  1. 1. Department of Genetics, College of Science, Islamic Azad University, Kazerun Branch, Kazerun, Iran
  2. 2. School of Medicine, Iran University of Medical Science, Tehran, Iran
  3. 3. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran
  5. 5. Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Cytokine Published:2021


Abstract

Acute myeloid leukemia (AML) is a heterogeneous disease with high mortality that accounts for the most common acute leukemia in adults. Despite all progress in the therapeutic strategies and increased rate of complete remission, many patients will eventually relapse and die from the disease. Cytokines as molecular messengers play a pivotal role in the immune system. The imbalance release of cytokine has been shown to exert a significant influence on the progression of hematopoietic malignancies including acute myeloid leukemia. This article aimed to summarize current knowledge about cytokines and their critical roles in the pathogenesis, treatment, and survival of AML patients. © 2021 Elsevier Ltd
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