Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-En-Y Gastric Bypass: A Double-Blind, Randomized Trial Publisher Pubmed



Melali H1 ; Abdolahi A2 ; Sheikhbahaei E1, 3 ; Vakili K4 ; Mahmoudieh M1 ; Keleidari B1 ; Shahabi S3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Minimally Invasive Surgery and Obesity Research Center, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of General Surgery, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Iran University of Medical Sciences, Hazrat-E Rasool General Hospital, Masouri St. Niyayesh St. Satarkhan Ave., Tehran, 14665-354, Iran
  4. 4. Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Obesity Surgery Published:2024


Abstract

Purpose: Postoperative changes in gut microbiota may occur in patients undergoing Roux-en-Y gastric bypass surgery. In this study, we evaluate the impact of administering probiotic tablets on the gastrointestinal function and metabolic status of these patients. Materials and Methods: This double-blinded randomized clinical trial was conducted from 2021 to 2022 on 135 Roux-en-Y surgery candidates. The intervention group underwent the surgical procedure and started receiving probiotic supplements (Familact Co.) 1 week after surgery; the control group received a placebo. The laboratory and anthropometric data were measured and analyzed before and 3 and 6 months after the intervention. GIQLI questionnaire was also used at the beginning and 6 months after the intervention to evaluate GI symptoms. Results: We observed significantly reduced BMI in both groups after surgeries (P < 0.001). The levels of FBS and HbA1C were significantly lower in the probiotic group compared to the placebo in 3 months (P = 0.02 and P = 0.001, respectively) and 6 months (P < 0.001 for both) after the intervention. The levels of vitamin B12 increased significantly in the probiotic group (P < 0.001), and the values were substantially higher than the placebo group in 3 and 6 months (P < 0.001), respectively. Analysis of the GIQLI questionnaire before and 6 months after interventions also revealed significant improvement in the GIQLI score in both groups (P < 0.001 for probiotics and P = 0.03 for placebo). Conclusion: Probiotic supplement administration following RYGB improves patients’ vitamin and metabolic profile, as well as GI function, although it cannot significantly affect weight loss. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Related Docs
View other Related Docs
1. Systematic Review With Meta-Analysis: Effects of Probiotic Supplementation on Symptoms in Functional Dyspepsia, Journal of Functional Foods (2020)
2. The Effects of Probiotic Supplementation on Functional Constipation Following Colonoscopy: A Double-Blinded Randomized Controlled Trial, Current Nutrition and Food Science (2025)
3. A Comparative Study of the Effect of Two Procedures of Classic Roux-En-Y and Omega Bariatric Surgery on the Control and Management of Diabetes, Advanced Biomedical Research (2022)
4. Effect of Modified Jejunoileal Bypass Surgery on the Colon Microflora: A Case Study; [Efecto De La Cirugia De Derivacion Yeyunoileal Modificada Sobre La Microflora Del Colon: Estudio De Un Caso], Revista Latinoamericana de Hipertension (2022)
5. The Effects of 6 Mo of Supplementation With Probiotics and Synbiotics on Gut Microbiota in the Adults With Prediabetes: A Double Blind Randomized Clinical Trial, Nutrition (2020)
6. The Effects of Probiotics in Ulcerative Colitis Patients: A Randomized Controlled Double Blind Clinical Trial, Functional Foods in Health and Disease (2023)
7. The Early Results of the Laparoscopic Mini-Gastric Bypass/One Anastomosis Gastric Bypass on Patients With Different Body Mass Index, Journal of Obesity (2020)
8. Probiotics, Prebiotics, and Synbiotics in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials, Diabetes/Metabolism Research and Reviews (2024)
Experts (# of related papers)
View all Related Experts
Awat Feizi (11)
Behrooz Keleidari (9)
Other Related Docs
9. Probiotic and Synbiotic Supplementation Could Improve Metabolic Syndrome in Prediabetic Adults: A Randomized Controlled Trial, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
10. The Effects of Probiotics and Synbiotic Supplementation on Glucose and Insulin Metabolism in Adults With Prediabetes: A Double-Blind Randomized Clinical Trial, Acta Diabetologica (2018)
11. Midterm Outcomes of One Anastomosis Gastric Bypass for Patients With Bmi < 35 Kg/M2 From a Large Single Center, Surgical Endoscopy (2024)
12. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
13. The Association of Demographic Characteristics With the Rate of Weight Loss and Changes in Nutritional Factors (Albumin, Vitamin D3, Ferritin) One Year After One Anastomosis Gastric Bypass, Advanced Biomedical Research (2023)
14. The Effects of Probiotics on Body Weight and Biomarkers of Animal, Pakistan Journal of Nutrition (2013)
15. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
16. Evaluation and Comparison of Therapeutic Effects of Probiotics and Colloidal Bismuth Subcitrate on Abdominal Bloating, Caspian Journal of Internal Medicine (2023)
17. Comparison of the Effect of Sequential Use of Metronidazole and Probiotics With Probiotics Alone on Functional Bloating; [مقایسه اثر مصرف متوالی مترونیدازول و پروبیوتیک با پروبیوتیک به تنهایی بر نفخ عملکردی], Tehran University Medical Journal (2023)
18. Effects of Synbiotic Supplementation on Microbiota-Derived Protein-Bound Uremic Toxins, Systemic Inflammation, and Biochemical Parameters in Patients on Hemodialysis: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial, Nutrition (2020)
19. The Effectiveness of Synbiotics in Preventing Antibiotic-Associated Diarrhea in Children: A Double-Blind Randomized Clinical Trial, Archives of Pediatric Infectious Diseases (2019)
20. Remnant Gastrectomy and Gastric Bypass: A Systematic Review of Indications and Outcomes of Resectional Gastric Bypass, Obesity Surgery (2024)
21. Short-Term Outcomes of Bariatric Surgery in Patients With Obesity, Journal of Isfahan Medical School (2018)
22. Probiotics As a Novel Treatment for Non-Alcoholic Fatty Liver Disease; a Systematic Review on the Current Evidences, Hepatitis Monthly (2013)
23. Reversal to Normal Anatomy After One-Anastomosis/Mini Gastric Bypass, Indications and Results: A Systematic Review and Meta-Analysis, Surgery for Obesity and Related Diseases (2021)
24. Appetite Sensation Improvement by Synbiotic Supplementation in Patients With Metabolic Syndrome: A Randomized Controlled Clinical Trial, Food Science and Nutrition (2024)
25. Single-Anastomosis Sleeve Jejunal: A Mid-Term Follow-Up Report of a New Surgical Technique, Obesity Surgery (2023)
26. Metabolomics Analysis Revealed Metabolic Changes in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Metabolic Responses to a Synbiotic Yogurt Intervention, European Journal of Nutrition (2019)
27. What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery, International Journal of Endocrinology and Metabolism (2023)
28. Comparison of the Effects of Special Care Enhanced Recovery and Conventional Recovery Methods After Mini Omega Gastric Bypass, Advanced Biomedical Research (2023)
29. Effects of Antecolic Versus Retrocolic Duodenojejunostomy on Delayed Gastric Emptying After Pyloric Preserving Pancreaticoduodenectomy in Patients With Periampullary Tumors, Asian Journal of Surgery (2019)
30. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats, International Journal of Preventive Medicine (2024)
31. The Effect of Laparoscopic Sleeve Gastrectomy on Serum Levels of Vitamin A, D and B12 and Iron Profile on Patients With Morbid Obesity, Advanced Biomedical Research (2023)
32. The Two Different Biliopancreatic Limb Lengths for Roux-En-Y Gastric Bypass, Obesity Medicine (2019)
33. A Randomized Controlled Trial Investigating the Effect of a Diet Low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols on the Intestinal Microbiome and Inflammation in Patients With Ulcerative Colitis: Study Protocol for a Randomized Controlled Trial, Trials (2020)
34. Effects of Probiotic Supplementation on Semen Parameters After Varicocelectomy: A Randomized Controlled Trial, Journal of Research in Medical Sciences (2023)
35. The Effects of Probiotic and Synbiotic Supplementation on Metabolic Syndrome Indices in Adults at Risk of Type 2 Diabetes: Study Protocol for a Randomized Controlled Trial, Trials (2017)
36. A Meta-Analysis of the Effect of Probiotic Administration on Age-Related Sarcopenia, Food Science and Nutrition (2023)
37. Effects of Synbiotic Supplementation on Anthropometric Indices and Body Composition in Overweight or Obese Children and Adolescents: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, World Journal of Pediatrics (2023)
38. The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study, Iranian Red Crescent Medical Journal (2017)
39. The Effects of Spirulina Supplementation on Serum Iron and Ferritin, Anemia Parameters, and Fecal Occult Blood in Adults With Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial, Clinical Nutrition ESPEN (2023)
40. Effect of Enteral Probiotics on Prognostic Scores and C-Reactive Protein Levels in Critically Ill Multiple Trauma Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Clinical Nutrition ESPEN (2023)
41. The Effect of Pumpkin and Probiotic Yogurt Consumption Separately Or/And Simultaneously on Type Ii Diabetes, Journal of Isfahan Medical School (2014)
42. The Effect of Daily Consumption of Probiotic Yogurt on Liver Enzymes, Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease (Nafld): Study Protocol for a Randomized Clinical Trial, BMC Gastroenterology (2022)
43. Therapeutics Effects of Bovine Colostrum Applications on Gastrointestinal Diseases: A Systematic Review, Systematic Reviews (2024)
44. One Anastomosis/Mini-Gastric Bypass (Oagb/Mgb) As Revisional Surgery Following Primary Restrictive Bariatric Procedures: A Systematic Review and Meta-Analysis, Obesity Surgery (2021)
45. Effect of Multispecies Probiotic Supplements on Metabolic Profiles, Hs-Crp, and Oxidative Stress in Patients With Type 2 Diabetes, Annals of Nutrition and Metabolism (2013)
46. The Effect of Glutamine Intake on Complications of Colorectal and Colon Cancer Treatment: A Systematic Review, Journal of Research in Medical Sciences (2015)
47. Synbiotic Containing Bacillus Coagulans and Fructo-Oligosaccharides for Functional Abdominal Pain in Children, Gastroenterology and Hepatology from Bed to Bench (2015)
48. The Effects of Probiotic Supplementation on Markers of Blood Lipids, and Blood Pressure in Patients With Prediabetes: A Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
49. Comparative Effectiveness of Roux-En-Y Gastric Bypass Vs. One Anastomosis Gastric Bypass on Kidney Function, Obesity Surgery (2021)
50. Comparison of the Bile Reflux Frequency in One Anastomosis Gastric Bypass and Roux-En-Y Gastric Bypass: A Cohort Study, Obesity Surgery (2019)