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Association of Rs8066560 Variant in the Sterol Regulatory Element-Binding Protein 1 (Srebp-1) and Mir-33B Genes With Hyperglycemia and Insulin Resistance Publisher Pubmed



Nikpour P1, 2, 3 ; Miranzadehmahabadi H4 ; Emadibaygi M4, 5 ; Kelishadi R1
Authors
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Authors Affiliations
  1. 1. Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Genetics, School of Basic Sciences, Shahrekord University, Shahrekord, Iran
  5. 5. Research Institute of Biotechnology, School of Basic Sciences, Shahrekord University, Shahrekord, Iran

Source: Journal of Pediatric Endocrinology and Metabolism Published:2014


Abstract

Objective: This study aims to evaluate the association of miR-33b/SREBP-1 rs8066560 with hyperglycemia and insulin resistance in Iranian children and adolescents.; Methods: This case-control study comprised 200 participants with 9-19 years of age, consisting of 100 MetS and 100 healthy controls. Anthropometric and biochemical parameters were measured, and the polymorphism was genotyped by TaqMan real-time PCR method.; Results: Logistic regression analysis of genotype distribution of rs8066560 did not show a significant association with MetS neither in boys (OR, 1.745; 95% CI, 0.695-4.382; p = 0.236) nor in girls (OR, 1.075; 95% CI, 0.420-2.752; p = 0.880). Participants with GG/AG genotypes had significant higher LDL-C levels than those with the AA genotype. No statistically significant difference was documented in fasting blood glucose and insulin levels between the three rs8066560 genotypes.; Conclusions: We found that rs8066560 variant on SREBP-1 and miR-33b genes is associated with LDL-C levels; however, it may not be an important determinant for the MetS, hyperglycemia, and insulin resistance in children and adolescents.
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