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Lipid Regulatory Genes Polymorphism in Children With and Without Obesity and Cardiometabolic Risk Factors: The Caspian-Iii Study Publisher

Summary: Study links specific gene variants to obesity & heart risks in kids, with some protecting against obesity. #Genetics #CardiometabolicHealth

Hovsepian S1 ; Javanmard SH2 ; Mansourian M3 ; Hashemipour M4 ; Tajadini M2 ; Kelishadi R5
Authors

Source: Journal of Research in Medical Sciences Published:2018


Abstract

Background: Genetically, predisposed children are considered as at-risk individuals for cardiovascular disease. In this study, we aimed to compare the frequency of four-lipid regulatory polymorphism in obese and normal-weight children with and without cardiometabolic risk factors. Materials and Methods: In this nested case–control study, 600 samples of four groups of participants consisted of those with normal weight with and without cardiometabolic risk factors and obese with and without cardiometabolic risk factors. Allelic and genotypic frequencies of GCKR (rs780094), GCKR (rs1260333), MLXIPL (rs3812316), and FADS (rs174547) polymorphisms were compared in the four studied groups. Results: Data of 528 samples were complete and included in this study. The mean (standard deviation) age of participants was 15.01 (2.21) years. Frequency of tt allele (minor allele) of GCKR (rs1260333) polymorphism was significantly lower in normal weight metabolically healthy participants than metabolically unhealthy normal weight (MUHNW) and obese children with and without cardiometabolic risk factor (P = 0.01). Frequency of ga allele of GCKR (rs780094) polymorphism was significantly higher in normal weight children with cardiometabolic risk factor than in their obese counterparts with cardiometabolic risk factor (P = 0.04). Frequency of cg and gg alleles (minor type) of MLXIPL (rs3812316) polymorphism in normal weight metabolically healthy participants was significantly higher than MUHNW (P = 0.04) and metabolically healthy obese children (P = 0.04). Conclusion: The findings of our study indicated that the minor allele of GCKR (rs1260333) single nucleotide polymorphisms (SNPs) could have pathogenic effect for obesity and cardiometabolic risk factors. Ga allele of GCKR (rs780094) SNPs had a protective effect on obesity. Minor alleles of MLXIPL (rs3812316) could have a protective effect for obesity and cardiometabolic risk factors. © 2018 Journal of Research in Medical Sciences.
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Roya Kelishadi (18)
Shaghayegh Haghjooy Javanmard (6)
Lipid Regulatory Genes Polymorphism in Children With and Without Obesity and Cardiometabolic Risk Factors: The Caspian-Iii Study
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