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Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different Fto Genotypes Publisher Pubmed



Roumi Z1 ; Salimi Z2 ; Mahmoudi Z1 ; Mobarakeh KA3 ; Ladaninezhad M4 ; Zeinalabedini M5 ; Keshavarzmohammadian M1 ; Shamsigoushki A6 ; Saeedirad Z7 ; Bahar B8 ; Khoshdooz S9 ; Kalantari N10 ; Azizitabesh G11 ; Doaei S10 Show All Authors
Authors
  1. Roumi Z1
  2. Salimi Z2
  3. Mahmoudi Z1
  4. Mobarakeh KA3
  5. Ladaninezhad M4
  6. Zeinalabedini M5
  7. Keshavarzmohammadian M1
  8. Shamsigoushki A6
  9. Saeedirad Z7
  10. Bahar B8
  11. Khoshdooz S9
  12. Kalantari N10
  13. Azizitabesh G11
  14. Doaei S10
  15. Gholamalizadeh M12
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Clinical Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences, University of Central Lancashire, Preston, United Kingdom
  9. 9. Faculty of Medicine, Guilan University of Medical Science, Rasht, Iran
  10. 10. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Endocrinology, Diabetes and Metabolism Published:2024


Abstract

Background: The FTO gene polymorphisms may influence the effects of lifestyle interventions on obesity. The present study aimed to assess the influence of the rs9930506 FTO gene polymorphism on the success of a comprehensive weight loss intervention in male adolescents with overweight and obesity. Methods: This study was carried out on 96 adolescent boys with overweight and obesity who were randomly assigned to the intervention (n = 53) and control (n = 43) groups. The blood samples of the participants were collected, and the FTO gene was genotyped for the rs9930506 polymorphism. A comprehensive lifestyle intervention including changes in diet and physical activity was performed for 8 weeks in the intervention group. Results: Following the lifestyle intervention, BMI and fat mass decreased significantly in the intervention group compared with the control group (both p < 0.05), while no change was found in weight, height or body muscle percentage between the groups. The participants in the intervention group with the AA/AG genotype and not in carriers of the GG genotype had a significantly higher reduction in BMI (−1.21 vs. 1.87 kg/m2, F = 4.07, p < 0.05) compared with the control group. Conclusion: The intervention in individuals with the AA/AG genotype has been significantly effective in weight loss compared with the control group. The intervention had no association effect on anthropometric indices in adolescents with the GG genotype of the FTO rs9930506 polymorphism. Trial Registration: Name of the registry: National Nutrition and Food Technology Research Institute; Trial registration number: IRCT2016020925699N2; Date of registration: 24/04/2016; URL of trial registry record: https://www.irct.ir/trial/21447. © 2024 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
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