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Urinary 1-Hydroxypyrene As a Biomarker of Carcinogenic Polycyclic Aromatic Hydrocarbons in Iranian Carbon Anode Plant Workers Publisher



Zare M1, 2, 3 ; Shahtaheri SJ1 ; Mehdipur P4 ; Shekari M5 ; Hajaghazadeh M1 ; Shahriary A6, 7 ; Abedinejad M3
Authors
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Authors Affiliations
  1. 1. Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Occupational Health Engineering, School of Public Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  3. 3. Research Centre for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  4. 4. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  6. 6. Environment Research Center and Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Health, Golestan University of Medical Sciences, Gorgan, Iran

Source: International Journal of Environmental Health Engineering Published:2012


Abstract

Aims: This study was designed to evaluate the validity of urinary 1-hydroxypyrene as a biomarker in carcinogenic PAHs (cPAHs) exposed Iranian carbon anode plant workers. Materials and Methods: The study population consisted of 42 workers working in a carbon anode plant and control group consisted of 43 office workers. Personal air sampling was performed to assess workers atmospheric exposure to carcinogenic PAHs. Urine samples were collected for analysis of urinary 1-hydroxypyrene using high performance liquid chromatography (HPLC). Statistical analysis was performed with SPSS version 16 software. Results: The mean concentration of occupational exposure to cPAHs in the exposed group was 11.42 7.56 ?g/m3. Mean level of urinary 1-hydroxypyrene in the exposed and control groups were 6.32 4.9 and 0.54 .48 ?mole/mole creatinine, respectively. Urinary level of 1-hydroxypyrene in the exposed group was significantly higher than the control group (P.0.001). A strong and significant correlation between total cPAHs exposure and urinary 1-hydroxypyrene (r=0.79, P.0.001) was found. Conclusion: The results confirm urinary 1-hydroxypyrene level as a good biomarker in cPAHs exposed workers. In addition, considering the level of urinary 1-hydroxypyrene, it can be concluded that studied carbon anode plant workers are exposed to substantial risk of cancer and other genotoxic effects which are the result of cPAHs exposure. © 2012 Medknow. All Rights Reserved.
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