Low Dose Intravenous Midazolam for Prevention of Ponv, in Lower Abdominal Surgery Pubmed



Safavi MR¹ ; Honarmand A¹ Show Affiliations
Source: Middle East Journal of Anesthesiology Published:2009

Abstract

Background: The aim of the present study was to compare anti-emetic efficacy of low dose midazolam premedication (35 μg/kg) 15 minutes before induction of anesthesia with midazolam (35 μg/kg) administered intravenously 30 min before conclusion of surgery, in patients undergoing lower abdominal surgery under general anesthesia. Methods: Sixty patients were assigned to one of three equal groups: Group MP (n = 20), which received intravenous midazolam 35 μg/kg in a volume of 3 ml 15 minutes before induction of anesthesia and 3 ml normal saline 30 minutes before extubation. Group MI (n = 20), which received 3 ml normal saline 15 minutes before induction of anesthesia and intravenous midazolam 35 μg/kg in a volume of 3 ml 30 minutes before extubation. Group NS (n = 20), which received 3 ml normal saline 15 minutes before induction of anesthesia plus 3 ml normal saline 30 minutes before extubation. Assessments of the occurrence of postoperative nausea and vomiting (PONV) were made at regular intervals for the first 24h. Results: Incidence of PONV was significantly lower in Group MI compared with Group NS and Group MP at 6, 12, 18, and 24 hours after operation (P < 0.05). The time for the first episode of PONV was significantly higher in Group MI compared with Group NS and Group MP (P < 0.05). Conclusion: Our results indicated that midazolam 35 μg/kg (2 mg) given intravenously 30 minutes before the end of surgery was more effective in decreasing the incidence of PONV than midazolam premedication 35 μg/kg.